PCDH7

Description		protocadherin 7
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GO Annotations	Cellular Component	Plasma Membrane Membrane Platelet Alpha Granule Membrane Glutamatergic Synapse
	Molecular Function	Calcium Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Pathways		Platelet degranulation RHOA GTPase cycle RHOB GTPase cycle
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Alzheimer's disease (late onset) ( 30820047) Attention deficit hyperactivity disorder ( 32279069) Body size at age 10 ( 32376654) Depressive symptom (sleep problems) (binary trait) ( 31530331) Diastolic blood pressure x smoking status (ever vs never) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Diffusing capacity of carbon monoxide ( 30694715) Electroencephalogram traits ( 25387704) Epilepsy ( 25087078) General risk tolerance (MTAG) ( 30643258) Generalized epilepsy ( 30531953) Hip circumference adjusted for BMI ( 28552196) Influenza A (H1N1) infection ( 26379185) Lipid traits ( 22028671) Mean arterial pressure x educational attainment (some college) interaction (2df) ( 32372009) Menarche (age at onset) ( 25231870) Mild influenza (H1N1) infection ( 26379185) Mouth morphology (principal component model) ( 30174134) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Refractive astigmatism ( 25367360) Refractive error ( 32231278) Response to antipsychotic treatment in schizophrenia ( 29503163) Response to ziprazidone in schizophrenia ( 29503163) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 34074324) Underweight status ( 25133637) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659) White matter hyperintensities in ischemic stroke ( 26674333)
Novel Interacting Genes		7 novel interacting genes: BST1 CD38 PDLIM5 PPARGC1A RFC1 RPIA SPP1
Interacting Genes		2 interacting genes: MTDH PPP1CA
Entrez ID		5099
HPRD ID		04288
Ensembl ID		ENSG00000169851
Uniprot IDs		A0A8Q3SI70 A0A8V8TM73 O60245
PDB IDs		2YST
Enriched GO Terms of Interacting Partners?		NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Phosphorus-oxygen Lyase Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cadherin Binding Involved In Cell-cell Adhesion Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Bone Resorption Positive Regulation Of B Cell Proliferation Regulation Of Bone Remodeling Positive Regulation Of Glucose Metabolic Process Regulation Of B Cell Proliferation Circadian Regulation Of Gene Expression Generation Of Precursor Metabolites And Energy Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Ribose-5-phosphate Isomerase Activity Hydrolase Activity, Acting On Glycosyl Bonds Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Biosynthetic Process Regulation Of Tissue Remodeling Positive Regulation Of B Cell Activation Carbohydrate Metabolic Process RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity DNA Clamp Unloader Activity Positive Regulation Of Estradiol Secretion Regulation Of Neuron Projection Development Telomere Maintenance Regulation Of Glucose Metabolic Process Nicotinamide Nucleotide Metabolic Process Regulation Of Circadian Rhythm Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Elg1 RFC-like Complex Regulation Of Estradiol Secretion D-ribose Metabolic Process Regulation Of B Cell Activation Extracellular Exosome Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Neuron Projection Development Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Telomere Organization Circadian Rhythm Transcription Coregulator Activity Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription
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