SOST

Description		sclerostin
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Protein-containing Complex
	Molecular Function	Protein Binding Heparin Binding Carbohydrate Binding BMP Binding DNA-binding Transcription Factor Binding Molecular Function Inhibitor Activity
	Biological Process	Ossification Response To Mechanical Stimulus Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ossification BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of DNA-templated Transcription Canonical Wnt Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Drugs		Romosozumab
Diseases		SOST related disorders, including: Sclerosteosis ; Endosteal hyperostosis, van Buchem type
GWAS		Bone mineral density (hip) ( 19079262 26733130) Bone mineral density (spine) ( 26733130) Eosinophil count ( 27863252) Femoral neck bone mineral density ( 22504420 29499414) Fractures ( 30158200 30598549) HDL cholesterol ( 25961943 27036123) Heel bone mineral density ( 28869591 30598549) High density lipoprotein cholesterol levels ( 33339817) Lumbar spine bone mineral density ( 29499414) Sum eosinophil basophil counts ( 27863252) Triglycerides ( 25961943)
Interacting Genes		1 interacting genes: PLEKHF2
Entrez ID		50964
HPRD ID		05762
Ensembl ID		ENSG00000167941
Uniprot IDs		Q9BQB4
PDB IDs		2K8P 3SOV 6L6R
Enriched GO Terms of Interacting Partners?		Lysosomal Transport Transport Vesicle Endosome Organization Endosome To Lysosome Transport Phosphatidylinositol Binding
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