NOX4

Description		NADPH oxidase 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Membrane NADPH Oxidase Complex Perinuclear Region Of Cytoplasm Anchoring Junction Cell Periphery Perinuclear Endoplasmic Reticulum
	Molecular Function	Nucleotide Binding Protein Binding Electron Transfer Activity NAD(P)H Oxidase H2O2-forming Activity Superoxide-generating NAD(P)H Oxidase Activity Oxidoreductase Activity Oxygen Sensor Activity Heme Binding Flavin Adenine Dinucleotide Binding Modified Amino Acid Binding Superoxide-generating NADPH Oxidase Activity Protein Tyrosine Kinase Binding
	Biological Process	Cell Morphogenesis Heart Process Superoxide Metabolic Process Defense Response Inflammatory Response Negative Regulation Of Cell Population Proliferation Gene Expression Intracellular Signal Transduction Superoxide Anion Generation Bone Resorption Homocysteine Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cardiac Muscle Cell Differentiation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucose Stimulus Reactive Oxygen Species Metabolic Process Reactive Oxygen Species Biosynthetic Process Positive Regulation Of DNA Biosynthetic Process
Pathways		Detoxification of Reactive Oxygen Species STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Aspartate aminotransferase levels ( 33547301) Diastolic blood pressure ( 30578418) Fish- and plant-related diet ( 32066663) Gut microbiota relative abundance (Streptococcus) ( 33208821) Health literacy ( 31250787) Height ( 31562340) Homocysteine levels ( 23824729) Obesity-related traits ( 23251661) Pulse pressure ( 30487518 30578418 29403010 28739976 28135244 27841878) Severe diabetic retinopathy in type 2 diabetes ( 30178632) Systolic blood pressure ( 30487518 30578418 27841878) Triglyceride levels ( 31647587 34074324)
Interacting Genes		2 interacting genes: PTPN11 TLR4
Entrez ID		50507
HPRD ID		09243
Ensembl ID		ENSG00000086991
Uniprot IDs		B3KQ17 B7Z523 B7Z529 E9PPP2 Q9NPH5
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Mechanical Stimulus Positive Regulation Of Interferon-beta Production Regulation Of Interferon-beta Production Positive Regulation Of Tumor Necrosis Factor Production Glial Cell Differentiation Positive Regulation Of Type I Interferon Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Myeloid Leukocyte Activation Regulation Of Type I Interferon Production Tissue Homeostasis Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Cell Activation Involved In Immune Response Regulation Of Tumor Necrosis Factor Production Leukocyte Activation Involved In Immune Response Anatomical Structure Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Nitric Oxide Production Involved In Inflammatory Response Response To Mechanical Stimulus Regulation Of Mononuclear Cell Proliferation Myeloid Cell Differentiation Regulation Of Protein Secretion Intestinal Epithelial Cell Migration Negative Regulation Of Interleukin-23 Production Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Detection Of Fungus Wound Healing Involved In Inflammatory Response MHC Class II Biosynthetic Process Regulation Of Leukocyte Proliferation Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Secretion By Cell Positive Regulation Of Secretion Response To Growth Factor Cerebellar Cortex Formation Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Lymphocyte Activation Negative Regulation Of Cytokine Production Negative Regulation Of Glucocorticoid Secretion Lipopolysaccharide Receptor Complex Positive Regulation Of Cell Activation Immune Effector Process Detection Of Lipopolysaccharide B Cell Proliferation Involved In Immune Response Regulation Of Protein-containing Complex Assembly Regulation Of Protein Transport Positive Regulation Of MAPK Cascade Regulation Of Innate Immune Response Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway
Tagcloud ?