OPA1

Name	OPA1 mitochondrial dynamin like GTPase
Structure
Interactors	2 interactors: APP BNIP3
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Microtubule Membrane Mitochondrial Crista Dendrite Mitochondrial Membrane Axon Cytoplasm
	Molecular Function	Nucleotide Binding Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding Lipid Binding Hydrolase Activity Phosphatidic Acid Binding GTPase-dependent Fusogenic Activity Membrane Bending Activity Cardiolipin Binding
	Biological Process	Mitochondrial Fission Neural Tube Closure Apoptotic Process Mitochondrion Organization Inner Mitochondrial Membrane Organization Visual Perception Mitochondrial Fusion Regulation Of Mitochondrion Organization Peroxisome Fission Axonal Transport Of Mitochondrion Positive Regulation Of Interleukin-17 Production Cristae Formation Negative Regulation Of Apoptotic Process GTP Metabolic Process Protein Complex Oligomerization Membrane Fusion Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Senescence Membrane Tubulation Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Mitochondrial Inner Membrane Fusion Positive Regulation Of T-helper 17 Cell Lineage Commitment Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways	Regulation of Apoptosis Mitochondrial protein degradation
Diseases	Autosomal dominant optic atrophy (DOA); Kjer's optic neuropathy Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS	Alcoholic chronic pancreatitis ( 28754779 ) Brain volume in infants (grey matter) ( 28763065 ) Dentures ( 31235808 ) Diastolic blood pressure ( 28270201 ) Major depressive disorder ( 27479909 ) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808 ) Psychological distress ( 30705256 )
Entrez ID	4976
HPRD ID	05596
Ensembl ID	ENSG00000198836
Uniprot IDs	E5KLJ9 E5KLK0 O60313
PDB IDs	6JTG 8CT1 8CT9 8EEW 8EF7 8EFF 8EFR 8EFS 8EFT
GO Terms Enriched among Interactors ?	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Intracellular Monoatomic Cation Homeostasis Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Metal Ion Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Inorganic Ion Homeostasis Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Response To Bacterium Lipoprotein Particle Growth Factor Receptor Binding Main Axon Response To Mechanical Stimulus Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Intracellular Monoatomic Ion Homeostasis Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cellular Response To Metal Ion Low-density Lipoprotein Particle Mediated Signaling Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Cellular Response To Cobalt Ion Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Endoplasmic Reticulum-autophagosome Adaptor Activity Autophagic Cell Death Mitochondrion Autophagosome Adaptor Activity Regulation Of Spontaneous Synaptic Transmission Regulation Of Membrane Potential NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Dendrite Monoatomic Ion Homeostasis Axon Choice Point Recognition Monoatomic Cation Homeostasis Negative Regulation Of Mitochondrial Fusion