ATP4A

Description		ATPase H+/K+ transporting subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Potassium:proton Exchanging ATPase Complex Membrane Apical Plasma Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding P-type Sodium:potassium-exchanging Transporter Activity ATP Binding P-type Potassium Transmembrane Transporter Activity P-type Potassium:proton Transporter Activity ATP Hydrolysis Activity Potassium Ion Binding Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Intracellular Sodium Ion Homeostasis Response To Xenobiotic Stimulus Regulation Of Proton Transport Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Intracellular Potassium Ion Homeostasis Monoatomic Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane PH Reduction Potassium Ion Transmembrane Transport Proton Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		Ion transport by P-type ATPases
Drugs		Pantoprazole Omeprazole Lansoprazole Esomeprazole Rabeprazole Dexlansoprazole Vonoprazan
Diseases
GWAS		Platelet count ( 29403010)
Interacting Genes		2 interacting genes: CLK1 UFL1
Entrez ID		495
HPRD ID		00668
Ensembl ID		ENSG00000105675
Uniprot IDs		A0A384MR29 P20648
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein K69-linked Ufmylation UFM1 Transferase Activity Regulation Of Reticulophagy Positive Regulation Of Reticulophagy UFM1 Ligase Activity Negative Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Protein Ufmylation Regulation Of IRE1-mediated Unfolded Protein Response Response To L-glutamate Positive Regulation Of Glial Cell Proliferation Reticulophagy Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Immune Response To Tumor Cell DNA Double-strand Break Processing NLRP3 Inflammasome Complex Assembly Negative Regulation Of Immune Response To Tumor Cell Hematopoietic Stem Cell Differentiation Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Response To Tumor Cell Negative Regulation Of T Cell Mediated Immunity Regulation Of Endoplasmic Reticulum Unfolded Protein Response Canonical Inflammasome Complex Assembly Rescue Of Stalled Ribosome Regulation Of Intracellular Estrogen Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Glial Cell Proliferation Blood Circulation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Signal Transduction By P53 Class Mediator Ribosome Disassembly DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Response To Endoplasmic Reticulum Stress
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