NELL1

Name	neural EGFL like 1
Structure
Interactors	10 interactors: ATN1 ATXN7 CACNA1A DYRK1A GFI1B HOXA1 MBD1 MEOX2 NUFIP2 RSPH1
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nuclear Envelope Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase C Binding Calcium Ion Binding Protein Binding Heparin Binding
	Biological Process	Nervous System Development Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Bone Mineralization Negative Regulation Of Osteoblast Proliferation Negative Regulation Of Protein Catabolic Process Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification
GWAS	Adverse response to lamotrigine and phenytoin ( 22379998 ) Attention function in attention deficit hyperactive disorder ( 26174813 ) Bone mineral density change response to combined chemotherapy in acute lymphoblastic leukemia ( 29266176 ) Cannabis use (initiation) ( 22823124 ) Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168 ) Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451 ) Crohn's disease ( 17684544 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Fibrinogen levels (smoking status, alcohol consumption or body mass index interaction) ( 25551457 ) Hepcidin levels ( 27846281 ) Hepcidin/transferrin saturation ratio ( 27846281 ) Hippocampal sclerosis ( 25188341 ) Methadone dose in opioid dependence ( 28115739 ) Obesity-related traits ( 23251661 ) Prudent dietary pattern ( 28644415 ) Response to amphetamines ( 22952603 ) Response to long-chain n-3 polyunsaturated fatty acid supplementation (change in triglyceride levels) ( 24847101 ) Triglyceride levels in HIV infection ( 33109212 ) Weight ( 28552196 )
Entrez ID	4745
HPRD ID	09081
Ensembl ID	ENSG00000165973
Uniprot IDs	B3KXR2 F5H6I3 J3KNC5 K9UUD5 Q92832
PDB IDs	6POL
GO Terms Enriched among Interactors ?	Nuclear Matrix Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone H3T45 Kinase Activity Semicircular Canal Formation Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nuclear Speck Regulation Of Microtubule Polymerization Or Depolymerization DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Abducens Nerve Formation Optokinetic Behavior Radial Spoke Head 1 Radial Spoke Head 3 Negative Regulation Of Heterochromatin Formation Double-stranded Methylated DNA Binding Somite Specification Radial Spoke Head Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cytoskeleton Organization Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Sequence-specific Double-stranded DNA Binding Outer Dense Fiber