ATIC

Description		5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Catalytic Activity IMP Cyclohydrolase Activity Phosphoribosylaminoimidazolecarboxamide Formyltransferase Activity Transferase Activity Hydrolase Activity Protein Homodimerization Activity Cadherin Binding
	Biological Process	Brainstem Development Nucleobase-containing Compound Metabolic Process Purine Nucleotide Biosynthetic Process GMP Biosynthetic Process 'de Novo' IMP Biosynthetic Process Cerebellum Development Cerebral Cortex Development Animal Organ Regeneration 'de Novo' AMP Biosynthetic Process Dihydrofolate Metabolic Process Tetrahydrofolate Biosynthetic Process 'de Novo' XMP Biosynthetic Process Cellular Response To Interleukin-7
Pathways		Purine ribonucleoside monophosphate biosynthesis Signaling by ALK fusions and activated point mutants
Drugs		Tetrahydrofolic acid Methotrexate Pemetrexed AICA ribonucleotide Guanosine-5'-Monophosphate 5-monophosphate-9-beta-D-ribofuranosyl xanthine Acid yellow 54 free acid N-[4-([(2-Amino-4-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-6-yl)methyl]{(2E)-3-[4-carbamoyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-5-yl]-2-propenoyl}amino)benzoyl]-L-glutamic acid
Diseases		AICA-ribosiduria; ATIC deficiency
GWAS		Airway imaging phenotypes ( 26030696) Metabolite levels ( 23823483)
Novel Interacting Genes		5 novel interacting genes: CIP2A CPS1 DES MAP3K7 VWC2L
Interacting Genes		6 interacting genes: CEBPA LINC01554 MTNR1A OGT RBM11 SERPINB5
Entrez ID		471
HPRD ID		03434
Ensembl ID		ENSG00000138363
Uniprot IDs		P31939 V9HWH7
PDB IDs		1P4R 1PKX 1PL0 5UY8 5UZ0
Enriched GO Terms of Interacting Partners?		Urea Metabolic Process Nitrogen Cycle Metabolic Process Urea Cycle
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