ATIC

Gene Name		5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
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Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	IMP Cyclohydrolase Activity Phosphoribosylaminoimidazolecarboxamide Formyltransferase Activity Protein Homodimerization Activity
	Biological Process	Brainstem Development Nucleobase-containing Compound Metabolic Process Purine Nucleobase Metabolic Process 'de Novo' IMP Biosynthetic Process Nucleoside Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Response To Inorganic Substance Cerebellum Development Cerebral Cortex Development Organ Regeneration Small Molecule Metabolic Process Dihydrofolate Metabolic Process Tetrahydrofolate Biosynthetic Process Nucleobase-containing Small Molecule Metabolic Process
Pathways		Purine ribonucleoside monophosphate biosynthesis Purine metabolism Metabolism of nucleotides
Drugs		Tetrahydrofolic acid Pemetrexed Aicar Guanosine-5\'-Monophosphate 5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine 2-[5-Hydroxy-3-Methyl-1-(2-Methyl-4-Sulfo-Phenyl)-1h-Pyrazol-4-Ylazo]-4-Sulfo-Benzoic Acid Beta-Dadf, Msa, Multisubstrate Adduct Inhibitor
Diseases
GWAS
Protein-protein Interactions		1 interactors: EGFR
Entrez ID		471
HPRD ID		03434
Ensembl ID		ENSG00000138363
Uniprot IDs		P31939
PDB IDs		1P4R 1PKX 1PL0
Enriched GO Terms of Interacting Partners?		Alkanesulfonate Metabolic Process Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Activation Of Phospholipase A2 Activity Positive Regulation Of Phospholipase A2 Activity Response To Cobalamin Response To UV-A Response To Hydroxyisoflavone Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Catenin Import Into Nucleus Regulation Of Phospholipase A2 Activity Regulation Of Superoxide Anion Generation Magnesium Ion Homeostasis Cellular Response To Estradiol Stimulus Protein Insertion Into Membrane Astrocyte Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Catenin Import Into Nucleus Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Cellular Response To Estrogen Stimulus Cellular Response To Dexamethasone Stimulus Positive Regulation Of Vasoconstriction Positive Regulation Of Vasodilation Hydrogen Peroxide Metabolic Process Morphogenesis Of An Epithelial Fold Response To Dexamethasone Positive Regulation Of DNA Repair Tongue Development Regulation Of Nitric-oxide Synthase Activity Astrocyte Differentiation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Salivary Gland Morphogenesis Regulation Of Vasodilation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Salivary Gland Development Negative Regulation Of ERBB Signaling Pathway Activation Of Phospholipase C Activity Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Cellular Response To Drug Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Phospholipase C Activity Regulation Of Vasoconstriction Exocrine System Development Regulation Of Nitric Oxide Biosynthetic Process Cellular Response To Amino Acid Stimulus
Tagcloud ?		analyses arthritis ccnd1 considered dhfr diagnosed genetic markers methotrexate monotherapy mthfr mtx multivariate newly option outcome pharmacogenetic ra respond rheumatoid rs1476413 rs1643650 rs16853826 rs17421511 suffer toxicity tyms variant variants