NDUFA1

Description		NADH:ubiquinone oxidoreductase subunit A1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex I
	Molecular Function	NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport
Pathways		Respiratory electron transport Complex I biogenesis
Drugs		NADH
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS
Interacting Genes		3 interacting genes: GOLGB1 TRIM55 TRIM63
Entrez ID		4694
HPRD ID		02093
Ensembl ID		ENSG00000125356
Uniprot IDs		O15239 Q6IBB5
PDB IDs		5XTC 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Protein Localization To Pericentriolar Material Ubiquitin Protein Ligase Activity Microtubule Diapedesis Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Muscle Atrophy Protein Localization To Centrosome Leukocyte Migration Involved In Inflammatory Response Macrophage Migration Protein Ubiquitination Innate Immune Response Protein Modification By Small Protein Conjugation M Band Negative Regulation Of Glycolytic Process Titin Binding Contractile Muscle Fiber Negative Regulation Of ATP Metabolic Process Defense Response To Other Organism Defense Response To Symbiont Golgi Stack Post-translational Protein Modification Response To Electrical Stimulus Negative Regulation Of Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Cis-Golgi Network Protein Localization To Cytoskeleton Regulation Of Glycolytic Process Canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Carbohydrate Catabolic Process Response To Other Organism Protein K63-linked Ubiquitination Regulation Of ATP Metabolic Process Regulation Of Cardiac Muscle Hypertrophy Endoplasmic Reticulum-Golgi Intermediate Compartment Immune Response Response To Interleukin-1 Regulation Of Purine Nucleotide Metabolic Process Response To External Biotic Stimulus Defense Response Regulation Of Non-canonical NF-kappaB Signal Transduction Protein K48-linked Ubiquitination Mononuclear Cell Migration
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