MUC4

Name	mucin 4, cell surface associated
Structure	No pdb structure
Interactors	5 interactors: EGFR ERBB2 ERBB3 ERBB4 GALNT11
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Plasma Membrane Membrane Extracellular Matrix Vesicle Extracellular Exosome
	Molecular Function	ErbB-2 Class Receptor Binding Extracellular Matrix Constituent, Lubricant Activity
	Biological Process	Cell Adhesion Cell-matrix Adhesion Maintenance Of Gastrointestinal Epithelium
Pathways	Defective GALNT3 causes HFTC Defective C1GALT1C1 causes TNPS Defective GALNT12 causes CRCS1 Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis
GWAS	Estimated glomerular filtration rate ( 31015462 ) Lung disease severity in cystic fibrosis ( 26417704 ) Red blood cell density in sickle cell anemia ( 28552477 )
Entrez ID	4585
HPRD ID	11829
Ensembl ID	ENSG00000145113
Uniprot IDs	A0A0G2JS65 A0T3F4 E9PDY6 Q99102
PDB IDs	Not available
GO Terms Enriched among Interactors ?	ERBB2 Signaling Pathway Basal Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Protein Tyrosine Kinase Activity Positive Regulation Of Epithelial Cell Proliferation Receptor Complex ERBB3:ERBB2 Complex Cellular Response To Epidermal Growth Factor Stimulus Epidermal Growth Factor Receptor Activity Basolateral Plasma Membrane Neuregulin Receptor Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Neuron Differentiation Regulation Of Epithelial Cell Proliferation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERBB2-EGFR Signaling Pathway Positive Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Protein Kinase Activity Kinase Activity Protein Tyrosine Kinase Activator Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Transferase Activity Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Signaling Receptor Activity Peripheral Nervous System Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Growth Negative Regulation Of Apoptotic Process Protein Localization To Postsynaptic Membrane Negative Regulation Of Programmed Cell Death Protein Localization To Postsynapse Positive Regulation Of Cell Population Proliferation Heart Development Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphate Metabolic Process