MTR

Gene Name		5-methyltetrahydrofolate-homocysteine methyltransferase
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Methionine Synthase Activity S-adenosylmethionine-homocysteine S-methyltransferase Activity Cobalamin Binding
	Biological Process	Sulfur Amino Acid Metabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Xenobiotic Metabolic Process Nervous System Development Methionine Biosynthetic Process Cobalamin Metabolic Process Methylation Cellular Nitrogen Compound Metabolic Process Pteridine-containing Compound Metabolic Process Small Molecule Metabolic Process
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective BTD causes biotidinase deficiency Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective UGT1A4 causes hyperbilirubinemia Sulfur amino acid metabolism Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Metabolic disorders of biological oxidation enzymes Metabolism of amino acids and derivatives Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective AMN causes hereditary megaloblastic anemia 1 Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defects in cobalamin (B12) metabolism Defective GSS causes Glutathione synthetase deficiency (GSS deficiency) Defective GIF causes intrinsic factor deficiency Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Cobalamin (Cbl, vitamin B12) transport and metabolism Phase II conjugation Methylation Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism
Drugs		Cyanocobalamin Tetrahydrofolic acid L-Methionine Hydroxocobalamin
Diseases
GWAS
Protein-protein Interactions		2 interactors: CDKN2A DYNLL1
Entrez ID		4548
HPRD ID		01136
Ensembl ID		ENSG00000116984
Uniprot IDs		B7ZLW7 Q99707
PDB IDs		2O2K
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Senescence-associated Heterochromatin Focus Assembly Negative Regulation Of Phosphorylation Positive Regulation Of Cellular Senescence Regulation Of Intracellular Transport Positive Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Cell Aging Positive Regulation Of Cell Death Regulation Of Establishment Of Protein Localization Mitotic Cell Cycle Process Positive Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of T Cell Differentiation In Thymus Heterochromatin Assembly Mitotic Cell Cycle Positive Regulation Of Protein Sumoylation Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Protein Localization Heterochromatin Organization Regulation Of Macrophage Apoptotic Process Replicative Senescence Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of B Cell Proliferation Regulation Of Protein Sumoylation Apoptotic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Programmed Cell Death Regulation Of Cellular Localization Cell Cycle Process Cell Death Death Protein Destabilization Regulation Of Execution Phase Of Apoptosis Regulation Of Cellular Senescence Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Somatic Stem Cell Division Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Senescence Regulation Of Protein Export From Nucleus Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Leukocyte Apoptotic Process Protein K63-linked Ubiquitination Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Tagcloud ?		accord accordance acquires acquisition autonomous counter ddd feral jyg kb mammary mc metastatic mtv oi145 oi165 oi320 oi96 shortening subline sublines t4 ta telomerase tpdmt trfs x10 x13 x2