MT-ND2

Description		NADH dehydrogenase subunit 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex I
	Molecular Function	Protein Binding NADH Dehydrogenase (ubiquinone) Activity Protein Kinase Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Response To Hypoxia Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Mitochondrial Respiratory Chain Complex I Assembly Proton Motive Force-driven Mitochondrial ATP Synthesis Reactive Oxygen Species Metabolic Process Proton Transmembrane Transport
Pathways		Mitochondrial translation termination Respiratory electron transport Complex I biogenesis Mitochondrial protein degradation
Drugs		NADH
Diseases		Leber optic atrophy; Leber hereditary optic atrophy (LHON)
GWAS
Interacting Genes		2 interacting genes: SRC STK11
Entrez ID		4536
HPRD ID		08952
Ensembl ID		ENSG00000198763
Uniprot IDs		P03891 Q7GXY9
PDB IDs		5XTC 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Negative Regulation Of TOR Signaling Negative Regulation Of TORC1 Signaling Regulation Of TORC1 Signaling Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Kinase Activity Protein Autophosphorylation Regulation Of TOR Signaling Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Kinase Activity Tissue Homeostasis Anatomical Structure Homeostasis Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Autophagy Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Protein Kinase Activity Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Kinase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Transport Intracellular Protein-containing Complex Cellular Response To Progesterone Stimulus Regulation Of Protein Phosphorylation Protein Phosphorylation Positive Regulation Of Cell Projection Organization Phosphorylation Positive Regulation Of Protein Modification Process Immune Response-activating Signaling Pathway Positive Regulation Of Vesicle Transport Along Microtubule Connexin Binding Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Phosphorylation Positive Regulation Of Dephosphorylation Positive Regulation Of Protein Localization LRR Domain Binding Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Neutrophil Activation Regulation Of Caveolin-mediated Endocytosis Osteoclast Development Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Lamellipodium Morphogenesis Multicellular Organismal-level Homeostasis Regulation Of Cellular Localization Signal Complex Assembly
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