AKR1B15

Description		aldo-keto reductase family 1 member B15
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Aldose Reductase (NADPH) Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Testosterone Dehydrogenase (NADP+) Activity Allyl-alcohol Dehydrogenase Activity Farnesol Dehydrogenase Activity All-trans-retinol Dehydrogenase (NADP+) Activity
	Biological Process	Lipid Metabolic Process Estrogen Biosynthetic Process Retinol Metabolic Process
Pathways		Estrogen biosynthesis
Drugs
Diseases
GWAS		Body mass index and systolic blood pressure (bivariate analysis) ( 33539483) Longevity ( 20834067)
Interacting Genes		1 interacting genes: TRAF2
Entrez ID		441282
HPRD ID		19151
Ensembl ID		ENSG00000227471
Uniprot IDs		C9JRZ8
PDB IDs
Enriched GO Terms of Interacting Partners?		TORC2 Complex Disassembly TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex CD27 Signaling Pathway Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Thioesterase Binding CD40 Receptor Complex CD40 Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of JUN Kinase Activity Interleukin-17-mediated Signaling Pathway TORC2 Signaling Cellular Response To Nitric Oxide Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Mitogen-activated Protein Kinase Kinase Kinase Binding Cellular Response To Reactive Nitrogen Species Response To Nitric Oxide Programmed Necrotic Cell Death Positive Regulation Of T Cell Cytokine Production Tumor Necrosis Factor Receptor Binding Non-canonical NF-kappaB Signal Transduction Positive Regulation Of MAP Kinase Activity Signal Transduction Involved In Regulation Of Gene Expression Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Interleukin-2 Production Vesicle Membrane Regulation Of T Cell Cytokine Production Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Regulation Of Interleukin-2 Production Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cytokine-mediated Signaling Pathway MRNA Stabilization Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Response To Cytokine Stimulus TORC1 Signaling Protein Autoubiquitination Negative Regulation Of MRNA Catabolic Process RNA Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Protein K63-linked Ubiquitination Regulation Of Immunoglobulin Production
Tagcloud ?