ASCL2

Name	achaete-scute family bHLH transcription factor 2
Structure	No pdb structure
Interactors	3 interactors: CALM1 CALM2 CALM3
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia In Utero Embryonic Development Placenta Development Regulation Of Transcription By RNA Polymerase II Nervous System Development Sensory Organ Development Negative Regulation Of Schwann Cell Proliferation Stem Cell Population Maintenance Cell Differentiation Neuron Differentiation T Cell Differentiation Somatic Stem Cell Population Maintenance Negative Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Spongiotrophoblast Layer Development Chorionic Trophoblast Cell Development T Follicular Helper Cell Differentiation Negative Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of T Cell Migration
GWAS	Celiac disease ( 23936387 ) Malaria ( 31844061 ) Serum metabolite levels ( 33031748 ) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926 ) Type 2 diabetes ( 25102180 31118516 )
Entrez ID	430
HPRD ID	03533
Ensembl ID	ENSG00000183734
Uniprot IDs	Q99929
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Calyx Of Held Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity Calcium Channel Complex Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Spindle Microtubule Presynaptic Endocytosis Substantia Nigra Development Calcium Channel Regulator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Sperm Midpiece Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Sarcomere Cell Cycle G2/M Phase Transition Neural Nucleus Development Negative Regulation Of Cation Transmembrane Transport Protein Serine/threonine Kinase Activator Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Voltage-gated Potassium Channel Complex Calcium-dependent Protein Binding Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Cytokinesis Vesicle-mediated Transport In Synapse Regulation Of Calcium-mediated Signaling Regulation Of Striated Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Monoatomic Ion Transport Regulation Of Heart Rate Detection Of Chemical Stimulus