MAP3K9

Name	mitogen-activated protein kinase kinase kinase 9
Structure
Novel Interactors	1 novel interactors: PIK3CA
Interactors	2 interactors: SH3RF1 SMURF1
GO Annotations	Cellular Component	Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Homodimerization Activity Protein Serine Kinase Activity Molecular Function Activator Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Apoptotic Process Signal Transduction Positive Regulation Of Apoptotic Process Protein Autophosphorylation
Drugs	12-(2-hydroxyethyl)-2-(1-methylethoxy)-13,14-dihydronaphtho[2,1-a]pyrrolo[3,4-c]carbazol-5(12H)-one Fostamatinib
GWAS	Anthropometric traits (multi-trait analysis) ( 30166351 ) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309 )
Entrez ID	4293
HPRD ID	15965
Ensembl ID	ENSG00000006432
Uniprot IDs	B4DZC4 G3V347 J3KPI6 P80192 Q8NEB1
PDB IDs	3DTC 4UY9
GO Terms Enriched among Interactors ?	Response To Butyrate Response To Ketone Cellular Response To Hydrostatic Pressure Response To Corticosteroid Lamellipodium Response To Steroid Hormone Positive Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Engulfment Of Target By Autophagosome Autosome Genomic Imprinting Response To Muscle Inactivity Regulation Of Developmental Growth Phosphatidylinositol 3-kinase Complex, Class IB Phosphatidylinositol 3-kinase Complex 1-phosphatidylinositol-4-phosphate 3-kinase Activity Transferase Activity Negative Regulation Of Fibroblast Apoptotic Process 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Positive Regulation Of Cell Projection Organization Response To Hydrostatic Pressure Activin Receptor Binding Ubiquitin Protein Ligase Activity Substrate Localization To Autophagosome Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Regulation Of Proteolysis Cardiac Muscle Cell Contraction Phosphatidylinositol 3-kinase Complex, Class IA 1-phosphatidylinositol-3-kinase Activity Response To Water Response To Inactivity Anoikis MAP-kinase Scaffold Activity Relaxation Of Cardiac Muscle Insulin Receptor Substrate Binding Protein Targeting To Vacuole Involved In Autophagy Ectoderm Development Response To L-leucine Regulation Of Developmental Process I-SMAD Binding Negative Regulation Of Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Binding Relaxation Of Muscle Regulation Of Fibroblast Apoptotic Process Regulation Of Growth Phosphatidylinositol-3-phosphate Biosynthetic Process Vascular Endothelial Growth Factor Signaling Pathway Genomic Imprinting Negative Regulation Of Anoikis