ME1

Name	malic enzyme 1
Structure
Novel Interactors	1 novel interactors: AP1B1
Interactors	2 interactors: MAPK1 OGT
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Magnesium Ion Binding Malic Enzyme Activity Malate Dehydrogenase (decarboxylating) (NADP+) Activity Protein Binding Oxaloacetate Decarboxylase Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Manganese Ion Binding Identical Protein Binding ADP Binding Metal Ion Binding NADP Binding NAD Binding
	Biological Process	Carbohydrate Metabolic Process Pyruvate Metabolic Process Malate Metabolic Process NADP+ Metabolic Process Nucleotide Biosynthetic Process Response To Hormone Response To Carbohydrate NAD+ Metabolic Process Protein Homotetramerization Regulation Of NADP Metabolic Process
Pathways	PPARA activates gene expression Pyruvate metabolism NFE2L2 regulating TCA cycle genes Regulation of pyruvate metabolism
Drugs	NADH Nicotinamide adenine dinucleotide phosphate
GWAS	Bipolar disorder ( 33169155 ) Birth weight ( 31043758 ) Serum polyunsaturated fatty acid concentration x Mediterranean diet adherence interaction in metabolic syndrome ( 31991592 )
Entrez ID	4199
HPRD ID	01102
Ensembl ID	ENSG00000065833
Uniprot IDs	P48163
PDB IDs	2AW5 3WJA 7X11 7X12
GO Terms Enriched among Interactors ?	Heart Development Basolateral Protein Secretion Early Endosome Regulation Of Lipid Metabolic Process Cardiac Neural Crest Cell Development Involved In Heart Development Caveolin-mediated Endocytosis Regulation Of Small Molecule Metabolic Process Regulation Of Golgi Inheritance Cytosine Metabolic Process Interleukin-34-mediated Signaling Pathway Cellular Response To Nutrient Levels Positive Regulation Of Macrophage Proliferation Trachea Formation Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Lipid Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex Non-canonical Inflammasome Complex Assembly Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of Transcription By Glucose Positive Regulation Of Peptidyl-threonine Phosphorylation RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Bergmann Glial Cell Differentiation NSL Complex Clathrin Adaptor Complex AP-1 Adaptor Complex Platelet Dense Granule Organization Melanosome Assembly Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Localization Response To Nutrient Levels Face Development Positive Regulation Of Neuroinflammatory Response Labyrinthine Layer Blood Vessel Development Regulation Of Golgi Organization Regulation Of Protein Modification Process Peptidyl-threonine Phosphorylation MAP Kinase Activity Pyrimidine Nucleobase Metabolic Process Cellular Homeostasis Positive Regulation Of Cholesterol Biosynthetic Process Schwann Cell Development