MAN2A1

Description		mannosidase alpha class 2A member 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Golgi Apparatus Golgi Medial Cisterna Cis-Golgi Network Membrane Extracellular Exosome
	Molecular Function	Catalytic Activity Alpha-mannosidase Activity Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase Activity Mannosidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Carbohydrate Binding Metal Ion Binding
	Biological Process	In Utero Embryonic Development Liver Development Carbohydrate Metabolic Process Mannose Metabolic Process Protein Glycosylation N-glycan Processing Mitochondrion Organization Vacuole Organization Respiratory Gaseous Exchange By Respiratory System Viral Protein Processing Lung Alveolus Development Positive Regulation Of Neurogenesis Retina Morphogenesis In Camera-type Eye
Pathways		Intra-Golgi traffic Maturation of spike protein Reactions specific to the complex N-glycan synthesis pathway
Drugs		Tridolgosir 2-deoxy-2-fluoro-alpha-D-mannosyl fluoride Ghavamiol Kifunensine 5-fluoro-beta-L-gulosyl fluoride 5-Thio-a/B-D-Mannopyranosylamine 1-deoxymannojirimycin (1R,2R,3R,4S,5R)-4-(Benzylamino)-5-(methylthio)cyclopentane-1,2,3-triol (1S,2S,3R,6R)-4-(hydroxymethyl)-6-(octylamino)cyclohex-4-ene-1,2,3-triol
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Autism spectrum disorder or schizophrenia ( 28540026) Exploratory eye movement dysfunction in schizophrenia (cognitive search score) ( 26242244) Exploratory eye movement dysfunction in schizophrenia (number of eye fixations) ( 26242244) Exploratory eye movement dysfunction in schizophrenia (responsive search score) ( 26242244) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels in HIV infection ( 33109212) Intelligence (MTAG) ( 29326435) Number of sexual partners ( 30643258) Schizophrenia ( 25056061 28991256 29483656 30285260) Triglyceride levels ( 34074324)
Novel Interacting Genes		2 novel interacting genes: APC EPB41L4A-AS1
Interacting Genes		1 interacting genes: SEC23B
Entrez ID		4124
HPRD ID		01110
Ensembl ID		ENSG00000112893
Uniprot IDs		Q16706
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt Signalosome Leading Edge Membrane Positive Regulation Of Pseudopodium Assembly Negative Regulation Of Microtubule Depolymerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Spindle Assembly Checkpoint Signaling Protein Kinase Regulator Activity Heart Valve Development Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Mitotic Metaphase/anaphase Transition Beta-catenin Destruction Complex Negative Regulation Of Cyclin-dependent Protein Kinase Activity Perinuclear Region Of Cytoplasm Catenin Complex Dynein Complex Binding Negative Regulation Of Protein Serine/threonine Kinase Activity Endocardial Cushion Morphogenesis Gamma-catenin Binding Microtubule Plus-end Binding Plasma Membrane Bounded Cell Projection Positive Regulation Of Protein Localization To Centrosome Regulation Of Protein Localization To Centrosome Vesicle Budding From Membrane COPII-coated Vesicle Budding COPII Vesicle Coat COPII-coated Vesicle Cargo Loading Vesicle Cargo Loading Endoplasmic Reticulum Exit Site Regulation Of Microtubule Depolymerization Negative Regulation Of Mitotic Nuclear Division
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