MAN2A1

Gene Name		mannosidase, alpha, class 2A, member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cis-Golgi Network Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase Activity Zinc Ion Binding Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Carbohydrate Binding
	Biological Process	In Utero Embryonic Development Liver Development Mannose Metabolic Process N-glycan Processing Mitochondrion Organization Vacuole Organization Respiratory Gaseous Exchange Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process Lung Alveolus Development Positive Regulation Of Neurogenesis Retina Morphogenesis In Camera-type Eye
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Transport to the Golgi and subsequent modification Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective MOGS causes MOGS-CDG (CDG-2b) N-glycan antennae elongation in the medial/trans-Golgi Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Reactions specific to the complex N-glycan synthesis pathway Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033)
Protein-protein Interactions		1 interactors: SEC23B
Entrez ID		4124
HPRD ID		01110
Ensembl ID		ENSG00000112893
Uniprot IDs		Q16706 Q49A69
PDB IDs
Enriched GO Terms of Interacting Partners?
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