ARSB

Description		arylsulfatase B
Image
GO Annotations	Cellular Component	Extracellular Region Lysosome Endoplasmic Reticulum Lumen Cell Surface Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	N-acetylgalactosamine-4-sulfatase Activity Arylsulfatase Activity Sulfuric Ester Hydrolase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Autophagy Lysosome Organization Lysosomal Transport Response To Nutrient Response To PH Regulation Of Epithelial Cell Migration Positive Regulation Of Neuron Projection Development Response To Estrogen Response To Methylmercury Colon Epithelial Cell Migration
Pathways		The activation of arylsulfatases CS/DS degradation MPS VI - Maroteaux-Lamy syndrome Neutrophil degranulation Glycosphingolipid catabolism
Drugs
Diseases		Mucopolysaccharidosis type VI (MPS6); Maroteaux-Lamy syndrome
GWAS		Attention deficit hyperactivity disorder ( 23728934) Birth weight ( 31043758) Blood and toenail selenium levels ( 25343990) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Depressive symptom improvement ( 30468137) Heel bone mineral density ( 30598549) Hippocampal atrophy ( 19668339) Iron status biomarkers ( 19084217) Macular thickness ( 30535121) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Non-word reading ( 30741946) Toenail selenium levels ( 25343990)
Novel Interacting Genes		2 novel interacting genes: ADAMTS6 FOXP2
Interacting Genes
Entrez ID		411
HPRD ID		08358
Ensembl ID		ENSG00000113273
Uniprot IDs		A8K4A0 P15848
PDB IDs		1FSU
Enriched GO Terms of Interacting Partners?		Putamen Development Caudate Nucleus Development Righting Reflex Vocal Learning Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Observational Learning Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Cerebellar Purkinje Cell Differentiation Auditory Behavior Mechanosensory Behavior Reflex Cell Differentiation In Hindbrain Vocalization Behavior Smooth Muscle Tissue Development Coronary Vasculature Development Positive Regulation Of Mesenchymal Cell Proliferation Aorta Development Regulation Of Mesenchymal Cell Proliferation Artery Development Cardiac Septum Development Transcription Coregulator Binding Lung Alveolus Development Cerebellum Development Animal Organ Development Neural Nucleus Development Skeletal Muscle Tissue Development Post-embryonic Development Cerebral Cortex Development Camera-type Eye Development Metalloendopeptidase Activity Lung Development
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