HES5

Description		hes family bHLH transcription factor 5
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chondrocyte Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Adhesion Notch Signaling Pathway Smoothened Signaling Pathway Nervous System Development Brain Development Positive Regulation Of Cell Population Proliferation Anterior/posterior Pattern Specification Oligodendrocyte Development Telencephalon Development Glial Cell Fate Commitment Neural Tube Development Central Nervous System Neuron Differentiation Central Nervous System Myelination Cell Differentiation Neuron Differentiation BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Regulation Of Myelination Inner Ear Auditory Receptor Cell Differentiation Camera-type Eye Development Regulation Of Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Regulation Of Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Maturation Animal Organ Development Positive Regulation Of Smooth Muscle Cell Proliferation Astrocyte Differentiation Oligodendrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation System Development Regulation Of Epithelial Cell Proliferation Regulation Of Neurogenesis Cartilage Development Inner Ear Receptor Cell Stereocilium Organization Protein-containing Complex Assembly Comma-shaped Body Morphogenesis S-shaped Body Morphogenesis Specification Of Loop Of Henle Identity Metanephric Nephron Tubule Morphogenesis Establishment Of Epithelial Cell Polarity Neuronal Stem Cell Population Maintenance Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation
Pathways		NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases
GWAS		Body mass index ( 26426971)
Interacting Genes		2 interacting genes: JAK2 STAT3
Entrez ID		388585
HPRD ID		16240
Ensembl ID		ENSG00000197921
Uniprot IDs		Q5TA89
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Positive Regulation Of Skeletal Muscle Cell Proliferation Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Interleukin-23-mediated Signaling Pathway Regulation Of Skeletal Muscle Satellite Cell Proliferation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of Skeletal Muscle Cell Proliferation Interleukin-6-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Interleukin-1 Beta Production Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Interleukin-1 Production Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of MRNA Metabolic Process Histone H3Y41 Kinase Activity Regulation Of Tumor Necrosis Factor Production Nuclear Receptor-mediated Mineralocorticoid Signaling Pathway Symbiont-induced Defense-related Programmed Cell Death Interleukin-35-mediated Signaling Pathway Regulation Of MRNA Stability Response To Wounding Regulation Of RNA Stability Intracellular Receptor Signaling Pathway Regulation Of Postsynapse To Nucleus Signaling Pathway Transcription By RNA Polymerase II Positive Regulation Of Phosphate Metabolic Process Interleukin-12 Receptor Complex Adaptive Immune Response Positive Regulation Of Growth Hormone Receptor Signaling Pathway Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Cytokine Production Cellular Response To Hormone Stimulus Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Response To Interleukin-12 Interleukin-23 Receptor Complex Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Activation Of Janus Kinase Activity RNA Sequestering Activity Cytokine-mediated Signaling Pathway Signaling Receptor Binding Type 1 Angiotensin Receptor Binding
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