HES5

Gene Name		hes family bHLH transcription factor 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Nucleoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Double-stranded DNA Binding Transcription Factor Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chondrocyte Differentiation Transcription, DNA-templated Protein Complex Assembly Cell Adhesion Notch Signaling Pathway Smoothened Signaling Pathway Brain Development Positive Regulation Of Cell Proliferation Oligodendrocyte Development Telencephalon Development Glial Cell Fate Commitment Forebrain Radial Glial Cell Differentiation Neural Tube Development Central Nervous System Myelination Positive Regulation Of BMP Signaling Pathway Regulation Of Myelination Auditory Receptor Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Auditory Receptor Cell Fate Determination Camera-type Eye Development Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JAK-STAT Cascade Cell Maturation Positive Regulation Of Smooth Muscle Cell Proliferation Astrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Regulation Of Neurogenesis Cartilage Development Comma-shaped Body Morphogenesis S-shaped Body Morphogenesis Specification Of Loop Of Henle Identity Metanephric Nephron Tubule Morphogenesis Neuronal Stem Cell Maintenance Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Forebrain Neuron Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 intracellular domain regulates transcription Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH2 Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: JAK2 STAT3
Entrez ID		388585
HPRD ID		16240
Ensembl ID		ENSG00000197921
Uniprot IDs		Q5TA89
PDB IDs
Enriched GO Terms of Interacting Partners?		JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Growth Hormone JAK-STAT Cascade Protein Import Into Nucleus Nuclear Import Protein Import Protein Localization To Nucleus Intracellular Receptor Signaling Pathway Host Programmed Cell Death Induced By Symbiont Histone H3-Y41 Phosphorylation Nucleocytoplasmic Transport Nuclear Transport Mineralocorticoid Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Establishment Of Protein Localization To Organelle Positive Regulation Of Growth Hormone Receptor Signaling Pathway Activation Of JAK2 Kinase Activity Interleukin-12-mediated Signaling Pathway Tyrosine Phosphorylation Of Stat1 Protein Tyrosine Phosphorylation Of Stat5 Protein Protein Targeting Cytokine-mediated Signaling Pathway Response To Peptide Hormone Regulation Of Growth Hormone Receptor Signaling Pathway STAT Protein Import Into Nucleus Response To Interleukin-12 Cellular Response To Organonitrogen Compound Response To Peptide Tyrosine Phosphorylation Of Stat3 Protein Protein Localization To Organelle Activation Of Janus Kinase Activity Cellular Response To Hormone Stimulus Cellular Response To Cytokine Stimulus Regulation Of Cell Migration Negative Regulation Of Glycolytic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Regulation Of Cell Motility Radial Glial Cell Differentiation Tyrosine Phosphorylation Of STAT Protein Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cell Proliferation Regulation Of Locomotion Regulation Of Cellular Component Movement Cytoplasmic Transport Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Response To Cytokine Positive Regulation Of Protein Import Into Nucleus, Translocation
Tagcloud ?		axonal axons cdk2 demyelinating depends devising disabilities electrical export fail inefficient insulation interfere limk mash1 myelin myelination oligodendrocytes oligodendroglial p57kip2 permanent propagation remyelination resident restoration sheaths sheds subcellular unmet