TMEM189-UBE2V1

Gene Name		TMEM189-UBE2V1 readthrough
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Gene Ontology Annotations	Cellular Component
	Molecular Function
	Biological Process
Pathways		Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade IRAK1 recruits IKK complex Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Class I MHC mediated antigen processing & presentation Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex Innate Immune System TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: TRAF6 UBE2N
Entrez ID		387522
HPRD ID		11926
Ensembl ID		ENSG00000240849
Uniprot IDs		A5PLL7 Q13404
PDB IDs		2A4D 2C2V 2HLW
Enriched GO Terms of Interacting Partners?		Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein K63-linked Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Antigen Receptor-mediated Signaling Pathway Activation Of Innate Immune Response Protein Polyubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Intracellular Receptor Signaling Pathway Regulation Of Protein Ubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Fc-epsilon Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Innate Immune Response Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Histone Ubiquitination Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Transferase Activity Protein Ubiquitination Cellular Response To Cytokine Stimulus DNA Double-strand Break Processing Positive Regulation Of Transcription Regulatory Region DNA Binding Protein Modification By Small Protein Conjugation Positive Regulation Of Immune Response Response To Cytokine Positive Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of Interleukin-6 Biosynthetic Process Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Immunoglobulin Secretion Regulation Of Interleukin-12 Biosynthetic Process
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