ITPA

Description		inosine triphosphatase
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Hydrolase Activity DITP Diphosphatase Activity ITP Diphosphatase Activity XTP Diphosphatase Activity Identical Protein Binding Metal Ion Binding Nucleoside Triphosphate Diphosphatase Activity
	Biological Process	ITP Catabolic Process Nucleotide Metabolic Process Nucleoside Triphosphate Catabolic Process Deoxyribonucleoside Triphosphate Catabolic Process Chromosome Organization
Pathways		Purine catabolism Ribavirin ADME
Drugs		Citric acid
Diseases
GWAS		Chronic hepatitis C infection ( 20173735) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels x loop diuretics use interaction ( 31806883) IFN-related cytopenia ( 21703177) Night sleep phenotypes ( 27126917) Refractive error ( 32231278) Response to hepatitis C treatment ( 21659334) Ribavirin-induced anemia ( 20637204)
Interacting Genes		1 interacting genes: CEBPA
Entrez ID		3704
HPRD ID		08856
Ensembl ID		ENSG00000125877
Uniprot IDs		A0A0S2Z3W7 A0A0S2Z423 Q8WWI0 Q9BY32
PDB IDs		2CAR 2I5D 2J4E 4F95
Enriched GO Terms of Interacting Partners?		RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex CHOP-C/EBP Complex White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Response To Lithium Ion Transcription By RNA Polymerase I Urea Metabolic Process Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion HMG Box Domain Binding Response To Phenylpropanoid Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Urea Cycle Interleukin-6-mediated Signaling Pathway STAT Family Protein Binding Osteoblast Development Fat Cell Proliferation Brown Fat Cell Differentiation Granulocyte Differentiation Positive Regulation Of Macrophage Activation Negative Regulation Of Stem Cell Proliferation Hematopoietic Stem Cell Proliferation Embryonic Placenta Development Epithelial Cell Maturation Acute-phase Response Integrated Stress Response Signaling Macrophage Differentiation Response To Dexamethasone Animal Organ Regeneration Regulation Of Macrophage Activation Inner Ear Development Acute Inflammatory Response Cellular Response To Xenobiotic Stimulus Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Initiation Energy Homeostasis Response To Vitamin Stem Cell Proliferation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Initiation Regulation Of Stem Cell Proliferation Chromatin DNA Binding Kinase Binding Notch Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
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