ISG20

Description		interferon stimulated exonuclease gene 20
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GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Nucleolus Cytoplasm Cajal Body PML Body
	Molecular Function	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding Nuclease Activity Exonuclease Activity Single-stranded DNA 3'-5' DNA Exonuclease Activity Exoribonuclease II Activity Hydrolase Activity U1 SnRNA Binding U2 SnRNA Binding U3 SnoRNA Binding Metal Ion Binding
	Biological Process	Immune System Process DNA Metabolic Process DNA Catabolic Process RRNA Processing RNA Processing RNA Catabolic Process Response To Virus Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus
Pathways		Interferon alpha/beta signaling
Drugs		Uridine monophosphate
Diseases
GWAS		Adult hearing aid use ( 31564434) Adult hearing difficulty ( 31564434) Age-related hearing impairment ( 27764096 34108613) Age-related hearing impairment (low/mid frequency) ( 31645637) Dupuytren's disease ( 21732829 28886342) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin ( 32888494) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Serum omega-6 polyunsaturated fatty acid concentration in metabolic syndrome ( 31991592) Serum total polyunsaturated fatty acid concentration in metabolic syndrome ( 31991592)
Novel Interacting Genes		2 novel interacting genes: NRG1 SCAND2P
Interacting Genes
Entrez ID		3669
HPRD ID		05169
Ensembl ID		ENSG00000172183
Uniprot IDs		H0YMM4 Q96AZ6
PDB IDs		1WLJ 7UGB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Activation Of Protein Kinase B Activity Ventricular Cardiac Muscle Cell Differentiation ErbB-3 Class Receptor Binding Positive Regulation Of Protein Autophosphorylation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB2-ERBB4 Signaling Pathway Endocardial Cell Differentiation ERBB4 Signaling Pathway Nickel Cation Binding ERBB4-ERBB4 Signaling Pathway Cardiac Muscle Cell Myoblast Differentiation Cardioblast Differentiation Regulation Of Protein Autophosphorylation Ventricular Trabecula Myocardium Morphogenesis Protein Tyrosine Kinase Activator Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Stem Cell Development Mammary Gland Development Positive Regulation Of Heart Growth Endothelial Cell Differentiation Heart Trabecula Morphogenesis Cardiac Muscle Cell Differentiation Myoblast Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Peripheral Nervous System Development Negative Regulation Of Striated Muscle Cell Apoptotic Process Neural Crest Cell Development ERBB2 Signaling Pathway Positive Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Chemorepellent Activity Activation Of Protein Kinase Activity Regulation Of Cardiac Muscle Cell Proliferation Negative Chemotaxis Positive Regulation Of Organ Growth Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cardiocyte Differentiation Positive Regulation Of Striated Muscle Cell Differentiation Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Muscle Cell Apoptotic Process Cardiac Muscle Tissue Morphogenesis Receptor Tyrosine Kinase Binding Regulation Of Heart Growth Regulation Of Receptor Internalization Striated Muscle Cell Differentiation
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