INPP5B

Description		inositol polyphosphate-5-phosphatase B
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GO Annotations	Cellular Component	Cytoplasm Endosome Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Plasma Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Neuron Projection
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Metal Ion Binding Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity Inositol Phosphate Phosphatase Activity
	Biological Process	In Utero Embryonic Development Lipid Metabolic Process Signal Transduction Spermatogenesis Flagellated Sperm Motility Inositol Phosphate Metabolic Process Phosphatidylinositol Dephosphorylation Regulation Of Protein Processing
Pathways		Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol
Drugs		D-Myo-Inositol-1,4-Bisphosphate
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Autoimmune thyroid disease ( 32581359) Blood protein levels ( 30072576) Eyebrow thickness ( 26926045) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Myocardial infarction ( 33532862) Pulse pressure ( 28739976) Red cell distribution width ( 27863252) Rheumatoid arthritis ( 24390342 30423114) Type 1 diabetes ( 34012112)
Novel Interacting Genes		1 novel interacting genes: PTPRF
Interacting Genes		2 interacting genes: APP SMURF1
Entrez ID		3633
HPRD ID		00924
Ensembl ID		ENSG00000204084
Uniprot IDs		B3KMW4 P32019
PDB IDs		3MTC 3N9V 4CML 5A7I 5A7J
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Regulation Of Plasma Membrane Bounded Cell Projection Organization Growth Cone Lamellipodium Regulation Of Cell Projection Organization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Chondroitin Sulfate Proteoglycan Binding Engulfment Of Target By Autophagosome Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Heparin Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Negative Regulation Of Receptor Binding Regulation Of Spontaneous Synaptic Transmission Regulation Of Developmental Growth NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Activin Receptor Binding Neuron Projection Axon Choice Point Recognition Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Neuronal Cell Body Heparan Sulfate Binding Signaling Receptor Activator Activity Substrate Localization To Autophagosome Regulation Of Proteolysis Axon Peptidase Activator Activity
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