ARHGAP40

Description		Rho GTPase activating protein 40
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	GTPase Activator Activity
	Biological Process	Signal Transduction Regulation Of Actin Filament Polymerization Regulation Of Small GTPase Mediated Signal Transduction
Pathways		RHOA GTPase cycle CDC42 GTPase cycle
Drugs
Diseases
GWAS		Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945)
Interacting Genes		2 interacting genes: CDC42 RHOA
Entrez ID		343578
HPRD ID
Ensembl ID		ENSG00000124143
Uniprot IDs		Q5TG30
PDB IDs
Enriched GO Terms of Interacting Partners?		Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Establishment Of Epithelial Cell Apical/basal Polarity Establishment Of Epithelial Cell Polarity Wnt Signaling Pathway, Planar Cell Polarity Pathway Substantia Nigra Development Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Stress Fiber Assembly Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cytokinesis Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Neural Nucleus Development G Protein Activity Regulation Of Cytokinesis Positive Regulation Of Cell Division Establishment Of Cell Polarity Cell Periphery Regulation Of Stress Fiber Assembly Striated Muscle Tissue Development Muscle Tissue Development Establishment Or Maintenance Of Cell Polarity Cell-cell Junction Organization Positive Regulation Of Cytoskeleton Organization Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cell Division Mitotic Cleavage Furrow Formation Midbody Regulation Of Cell-substrate Adhesion Postsynapse Actin Filament Organization Cell Junction Assembly Aortic Valve Formation Positive Regulation Of Cell Cycle Process Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Skeletal Muscle Satellite Cell Migration GBD Domain Binding Storage Vacuole Wnt Signaling Pathway Regulation Of Synapse Organization Beta Selection GTPase Activity Circulatory System Process
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