SLC6A19

Description		solute carrier family 6 member 19
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GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Exosome
	Molecular Function	Protein Binding Amino Acid Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity Symporter Activity Transmembrane Transporter Activity
	Biological Process	Amino Acid Transmembrane Transport Amino Acid Transport Response To Nutrient Neutral Amino Acid Transport Viral Life Cycle Sodium Ion Transmembrane Transport
Pathways		Amino acid transport across the plasma membrane SLC-mediated transport of neurotransmitters Defective SLC6A19 causes Hartnup disorder (HND) Defective SLC6A19 causes Hartnup disorder (HND)
Drugs
Diseases		Hartnup disorder Iminoglycinuria
GWAS		Pancreatic cancer ( 25086665) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolites ( 26352407) Urine 6-bromotryptophan levels in chronic kidney disease ( 32572055)
Interacting Genes		1 interacting genes: ACE2
Entrez ID		340024
HPRD ID		10596
Ensembl ID		ENSG00000174358
Uniprot IDs		Q695T7
PDB IDs		6M17 6M18 6M1D 7DWX 7V61 8I92 8I93 8WBY 8WBZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Peptidyl-dipeptidase Activity Entry Receptor-mediated Virion Attachment To Host Cell Viral Translation Viral Life Cycle Tryptophan Transport Positive Regulation Of Gap Junction Assembly Aromatic Amino Acid Transport Transporter Activator Activity Positive Regulation Of Cardiac Muscle Contraction Adhesion Of Symbiont To Host Cell Receptor-mediated Endocytosis Of Virus By Host Cell Receptor-mediated Virion Attachment To Host Cell Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Angiotensin Maturation Regulation Of Gap Junction Assembly Virion Attachment To Host Cell Drinking Behavior Adhesion Of Symbiont To Host Positive Regulation Of Striated Muscle Contraction Endocytosis Involved In Viral Entry Into Host Cell Positive Regulation Of Amino Acid Transport Metallocarboxypeptidase Activity Regulation Of Cardiac Conduction Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Carboxypeptidase Activity Maternal Process Involved In Female Pregnancy Peptide Hormone Processing Positive Regulation Of Heart Contraction Signaling Receptor Ligand Precursor Processing Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Muscle Contraction Brush Border Membrane Ceramide Biosynthetic Process Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Vasoconstriction Endocytic Vesicle Membrane Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Amine Transport Regulation Of Cardiac Muscle Contraction Virus Receptor Activity Organic Cation Transport Feeding Behavior Endopeptidase Activity Ceramide Metabolic Process Sphingolipid Biosynthetic Process Regulation Of Striated Muscle Contraction Positive Regulation Of Cell Junction Assembly
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