HTR3A

Description		5-hydroxytryptamine receptor 3A
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Cleavage Furrow Neuron Projection Synapse Postsynaptic Membrane Transmembrane Transporter Complex Serotonin-activated Cation-selective Channel Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Excitatory Extracellular Ligand-gated Monoatomic Ion Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Serotonin-gated Monoatomic Cation Channel Activity Identical Protein Binding Serotonin Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Monoatomic Ion Transport Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Inorganic Cation Transmembrane Transport Regulation Of Presynaptic Membrane Potential Serotonin-gated Cation-selective Signaling Pathway
Pathways		Neurotransmitter receptors and postsynaptic signal transmission
Drugs		Ziprasidone Methadone Olanzapine Clozapine Palonosetron Loxapine Amoxapine Lamotrigine Cisapride Paroxetine Procaine Trimipramine Rocuronium Dolasetron Granisetron Ethanol Ondansetron Alosetron Dopamine Memantine Ergoloid mesylate Bupropion Tubocurarine Ketamine Quetiapine Metoclopramide Aripiprazole Chlorprothixene Cilansetron Renzapride DDP733 DDP-225 Tapentadol Ticalopride Serotonin Cannabidiol Vortioxetine Ramosetron Setiptiline Dihydroergocornine Tropisetron Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Chronic kidney disease ( 26420894) Diisocyanate-induced asthma ( 25918132) Multiple sclerosis ( 31604244)
Interacting Genes		2 interacting genes: CANX HSPA5
Entrez ID		3359
HPRD ID		08917
Ensembl ID		ENSG00000166736
Uniprot IDs		B4E398 P46098
PDB IDs		8AXD 8BL8 8BLA 8BLB
Enriched GO Terms of Interacting Partners?		Protein Folding In Endoplasmic Reticulum Unfolded Protein Binding ERAD Pathway Protein Folding Regulation Of Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Cerebellum Structural Organization Endoplasmic Reticulum Lumen Regulation Of ATF6-mediated Unfolded Protein Response Proteasomal Protein Catabolic Process Protein Catabolic Process Calcium Ion Binding Regulation Of Protein Folding Maintenance Of Protein Localization In Endoplasmic Reticulum PERK-mediated Unfolded Protein Response ER Overload Response Post-translational Protein Targeting To Membrane, Translocation Endoplasmic Reticulum Chaperone Complex Negative Regulation Of PERK-mediated Unfolded Protein Response IRE1-mediated Unfolded Protein Response Cerebellar Purkinje Cell Layer Development Negative Regulation Of IRE1-mediated Unfolded Protein Response Proteolysis Involved In Protein Catabolic Process Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Misfolded Protein Binding Anatomical Structure Arrangement Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Melanosome Membrane Endoplasmic Reticulum Quality Control Compartment Cellular Response To Interleukin-4 Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Protein Serine/threonine Kinase Inhibitor Activity Viral Protein Processing Response To Interleukin-4 Protein Refolding Macromolecule Catabolic Process Endoplasmic Reticulum Membrane Lumenal Side Of Endoplasmic Reticulum Membrane Clathrin-dependent Endocytosis Intracellular Protein Transmembrane Transport Protein Transport COP9 Signalosome Regulation Of Endoplasmic Reticulum Unfolded Protein Response ER-nucleus Signaling Pathway ATP-dependent Protein Folding Chaperone Synaptic Vesicle Endocytosis Integrated Stress Response Signaling Proteolysis Presynaptic Endocytosis
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