HOXC6

Description		homeobox C6
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Embryonic Skeletal System Development
Pathways
Drugs
Diseases
GWAS		A body shape index ( 34021172) Hippocampal volume ( 25625606) Lumbar spine bone mineral density ( 22504420) Plateletcrit ( 32888494) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Waist circumference ( 28552196) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28552196 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Novel Interacting Genes		1 novel interacting genes: BRD2
Interacting Genes		9 interacting genes: APC APP BCAR3 CHEK2 FGFR2 HMGB1 IGF1R PTPRJ TGFB1
Entrez ID		3223
HPRD ID		00858
Ensembl ID		ENSG00000197757
Uniprot IDs		P09630
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Population Proliferation Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Signal Transduction Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Migration Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cell Activation Regulation Of Tumor Necrosis Factor Production Positive Chemotaxis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Oxygen-containing Compound Regulation Of Cell Communication Regulation Of Signaling Regulation Of Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Migration Regulation Of Leukocyte Migration Positive Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Cell Motility Positive Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Positive Regulation Of Chemokine Production Regulation Of Canonical Wnt Signaling Pathway Regulation Of Locomotion Insulin Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cellular Component Organization Regulation Of ERK1 And ERK2 Cascade Cell Surface Regulation Of Cell Activation Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Gamma-catenin Binding RAGE Receptor Binding
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