HOXB3

Description		homeobox B3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Hematopoietic Progenitor Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Rhombomere Development Glossopharyngeal Nerve Morphogenesis Thyroid Gland Development Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Regulation Of Neurogenesis Cartilage Development Definitive Hemopoiesis Face Development
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Body mass index ( 26426971) Body size at age 10 ( 32376654) Hand grip strength ( 29313844) Hemoglobin ( 32888494) Hypertension ( 31879980) Keratoconus ( 33649486)
Interacting Genes		3 interacting genes: CREBBP EP300 HMGB1
Entrez ID		3213
HPRD ID		00853
Ensembl ID		ENSG00000120093
Uniprot IDs		B3KNJ7 P14651
PDB IDs
Enriched GO Terms of Interacting Partners?		Damaged DNA Binding Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding N-terminal Protein Amino Acid Acetylation Peptidyl-lysine Acetylation Activation Of Innate Immune Response Regulation Of Cellular Response To Heat Acetyltransferase Activity Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Transcription Coactivator Activity Histone Acetyltransferase Complex Positive Regulation Of Innate Immune Response Protein-lysine-acetyltransferase Activity Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Histone Acetyltransferase Activity Protein Acetylation Activation Of Immune Response Regulation Of Innate Immune Response Tau Protein Binding Positive Regulation Of Defense Response Transcription Coactivator Binding Regulation Of Cellular Response To Stress Protein Destabilization Canonical NF-kappaB Signal Transduction Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Carbohydrate Catabolic Process P53 Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Chromatin Remodeling Positive Regulation Of Immune Response Regulation Of CD4-positive, Alpha-beta T Cell Activation Chromatin DNA Binding Cellular Response To UV DNA Damage Response Positive Regulation Of Protein Localization To Nucleus Regulation Of Glucose Metabolic Process Lung Development Regulation Of Defense Response Cellular Response To Light Stimulus Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Chromatin Organization Carbohydrate Catabolic Process Regulation Of Immune Response Negative Regulation Of Transcription By RNA Polymerase II Transcription Coregulator Activity
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