HMGCS1

Description		3-hydroxy-3-methylglutaryl-CoA synthase 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Hydroxymethylglutaryl-CoA Synthase Activity Protein Binding Transferase Activity Acyltransferase Activity Protein Homodimerization Activity
	Biological Process	Acetyl-CoA Metabolic Process Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Isoprenoid Biosynthetic Process Farnesyl Diphosphate Biosynthetic Process, Mevalonate Pathway Sterol Biosynthetic Process
Pathways		Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP)
Drugs		(7R,12R,13R)-13-formyl-12,14-dihydroxy-3,5,7-trimethyltetradeca-2,4-dienoic acid
Diseases
GWAS
Interacting Genes		4 interacting genes: CEBPA OGT SPOP WEE2-AS1
Entrez ID		3157
HPRD ID		07515
Ensembl ID		ENSG00000112972
Uniprot IDs		Q01581
PDB IDs		2P8U
Enriched GO Terms of Interacting Partners?		Regulation Of Proteolysis Chromatin DNA Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Proteolysis Carbohydrate Homeostasis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Glucose Homeostasis Regulation Of Proteasomal Protein Catabolic Process Response To Nutrient Response To Vitamin B2 White Fat Cell Proliferation C/EBP Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Pre-mRNA 5'-splice Site Binding Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Response To Phenylpropanoid Carbon Catabolite Regulation Of Transcription Fat Cell Proliferation MRNA 5'-splice Site Recognition Regulation Of Transcription By Glucose Urea Cycle STAT Family Protein Binding Regulation Of Protein Metabolic Process NSL Complex Urea Metabolic Process HMG Box Domain Binding Regulation Of Protein Catabolic Process Nitrogen Cycle Metabolic Process Response To Lithium Ion Transcription By RNA Polymerase I Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion White Fat Cell Differentiation Interleukin-6-mediated Signaling Pathway Osteoblast Development Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Acetylglucosaminyltransferase Activity U1 SnRNP Response To Nutrient Levels Sin3-type Complex Inflammatory Response
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