PADI1

Description		peptidyl arginine deiminase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein-arginine Deiminase Activity Calcium Ion Binding Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process
Pathways		Chromatin modifying enzymes
Drugs		Citrulline
Diseases
GWAS		Depression in multiple sclerosis ( 33296963) IgA nephropathy ( 25305756) Metabolite levels ( 23823483)
Interacting Genes		2 interacting genes: SQSTM1 TP53
Entrez ID		29943
HPRD ID		06395
Ensembl ID		ENSG00000142623
Uniprot IDs		Q9ULC6
PDB IDs		5HP5
Enriched GO Terms of Interacting Partners?		Receptor Tyrosine Kinase Binding Response To Ischemia Mitophagy Molecular Condensate Scaffold Activity Autophagy Of Mitochondrion Import Into Nucleus Protein Import Into Nucleus PML Body Regulation Of Mitochondrion Organization Macroautophagy Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Protein Localization To Nucleus Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Pentose-phosphate Shunt Ubiquitin Protein Ligase Binding Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Glucose Catabolic Process To Lactate Via Pyruvate Autophagy Germ Cell Nucleus Cellular Response To Actinomycin D Nuclear Transport Nucleocytoplasmic Transport Brown Fat Cell Proliferation Amphisome Establishment Of Protein Localization To Organelle Positive Regulation Of Thymocyte Apoptotic Process Response To Actinomycin D T Cell Proliferation Involved In Immune Response Regulation Of Autophagy Histone Deacetylase Regulator Activity Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Enzyme Binding Regulation Of G1 To G0 Transition Glial Cell Apoptotic Process Cellular Response To UV-C ATP-dependent DNA/DNA Annealing Activity DNA-templated Transcription B Cell Lineage Commitment Regulation Of Pentose-phosphate Shunt Lewy Body Response To Mitochondrial Depolarisation Mitochondrial DNA Repair Bone Marrow Development Stress-induced Premature Senescence Intracellular Membraneless Organelle Regulation Of NADP Metabolic Process
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