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CYP2S1
Gene Name
cytochrome P450, family 2, subfamily S, polypeptide 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Intracellular Membrane-bounded Organelle
Molecular Function
Iron Ion Binding
Arachidonic Acid Epoxygenase Activity
Steroid Hydroxylase Activity
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen
Oxygen Binding
Heme Binding
Aromatase Activity
Biological Process
Xenobiotic Metabolic Process
Epoxygenase P450 Pathway
Exogenous Drug Catabolic Process
Small Molecule Metabolic Process
Oxidation-reduction Process
Pathways
Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
Metabolic disorders of biological oxidation enzymes
Phase 1 - Functionalization of compounds
Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
Cytochrome P450 - arranged by substrate type
CYP2E1 reactions
Biological oxidations
Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
Defective FMO3 causes Trimethylaminuria (TMAU)
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
Miscellaneous substrates
Defective CYP1B1 causes Glaucoma
Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
Xenobiotics
Defective MAOA causes Brunner syndrome (BRUNS)
Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS
Protein-protein Interactions
1 interactors:
ADAMTSL4
Entrez ID
29785
HPRD ID
07481
Ensembl ID
ENSG00000167600
Uniprot IDs
Q96SQ9
PDB IDs
Enriched GO Terms of Interacting Partners
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Protein O-linked Fucosylation
Fucosylation
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