GTF2H3

Description		general transcription factor IIH subunit 3
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GO Annotations	Cellular Component	Core TFIIH Complex Portion Of Holo TFIIH Complex Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIH Holo Complex Transcription Preinitiation Complex
	Molecular Function	Protein Binding Zinc Ion Binding RNA Polymerase II General Transcription Initiation Factor Activity Metal Ion Binding
	Biological Process	DNA Repair Nucleotide-excision Repair Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II DNA Damage Response
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
GWAS		Gut microbiota relative abundance (Prevotella) ( 33208821) Late-onset Alzheimer's disease ( 27770636) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Novel Interacting Genes		1 novel interacting genes: SCARB1
Interacting Genes		7 interacting genes: AR CDK7 ERCC2 ERCC3 GTF2E1 UBC XBP1P1
Entrez ID		2967
HPRD ID		07531
Ensembl ID		ENSG00000111358
Uniprot IDs		A0A087WYD5 Q13889
PDB IDs		5IVW 5IY6 5IY7 5IY8 5IY9 5O85 5OF4 6NMI 6O9L 6O9M 6RO4 7AD8 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVW 7NVX 7NVY 7NVZ 7NW0 8BVW 8BYQ 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?		Transcription Initiation At RNA Polymerase II Promoter Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex DNA-templated Transcription Initiation Transcription By RNA Polymerase II Transcription Factor TFIID Complex DNA-templated Transcription CAK-ERCC2 Complex DNA-templated Transcription Elongation UV Protection Transcription-coupled Nucleotide-excision Repair Nucleobase-containing Compound Biosynthetic Process Hair Cell Differentiation Insulin-like Growth Factor Receptor Signaling Pathway DNA Helicase Activity RNA Metabolic Process Macromolecule Biosynthetic Process Transcription Elongation By RNA Polymerase II Nucleotide-excision Repair Prostate Induction Male Somatic Sex Determination Positive Regulation Of Sphingolipid Mediated Signaling Pathway High-density Lipoprotein Particle Receptor Activity High Density Lipoprotein Particle Mediated Signaling RNA Polymerase II CTD Heptapeptide Repeat S5 Kinase Activity Regulation Of Mitotic Cell Cycle Phase Transition Damaged DNA Binding Positive Regulation Of Mitotic Recombination Nucleotide-excision Repair Factor 3 Complex Endocytic Vesicle Membrane Epithelial Cell Differentiation Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Nucleic Acid Metabolic Process Regulation Of Sphingolipid Mediated Signaling Pathway Lipopolysaccharide Transport Regulation Of Cell Cycle Phase Transition Epidermal Cell Differentiation Transcription Factor TFIIE Complex Multicellular Organism Growth Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Integrin Biosynthetic Process Regulation Of Phosphatidylcholine Catabolic Process Regulation Of Mitotic Cell Cycle DNA Repair Transcription Factor TFIIK Complex Helicase Activity Male Genitalia Morphogenesis POU Domain Binding Isomerase Activity
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