GSTT1

Description		glutathione S-transferase theta 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Glutathione Transferase Activity Glutathione Peroxidase Activity Protein Binding Transferase Activity
	Biological Process	Glutathione Metabolic Process Cellular Oxidant Detoxification
Pathways		Glutathione conjugation Paracetamol ADME
Drugs		Glutathione Glutathione disulfide Deoxycholic acid
Diseases		Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
GWAS		Acne (severe) ( 24927181) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) S-phenylmercapturic acid levels in smokers ( 26959369) Urinary 1,3-butadiene metabolite levels in smokers ( 28292921)
Interacting Genes		1 interacting genes: ACTN2
Entrez ID		2952
HPRD ID		02700
Ensembl ID
Uniprot IDs		A0A0G2JRN4 A0A0G2JRQ5 P30711 Q4GZS9 Q4W251
PDB IDs		2C3N 2C3Q 2C3T
Enriched GO Terms of Interacting Partners?		Titin Z Domain Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Channel Activator Activity Microspike Assembly Phospholipase C-activating Angiotensin-activated Signaling Pathway Actin Filament Uncapping FATZ Binding LIM Domain Binding Positive Regulation Of Endocytic Recycling Postsynaptic Actin Cytoskeleton Positive Regulation Of Actin Filament Depolymerization Negative Regulation Of Protein Localization To Cell Surface Titin Binding Postsynaptic Cytoskeleton Organization Angiotensin-activated Signaling Pathway Regulation Of Endocytic Recycling Postsynaptic Density, Intracellular Component Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Protein Depolymerization Pseudopodium Positive Regulation Of Cation Channel Activity Focal Adhesion Assembly Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transport Regulation Of Protein Localization To Cell Surface Cell-substrate Junction Organization Positive Regulation Of Protein-containing Complex Disassembly Cell-substrate Junction Assembly Negative Regulation Of Potassium Ion Transport Positive Regulation Of Transporter Activity Cardiac Muscle Cell Development Sarcomere Organization Structural Constituent Of Muscle Cardiac Cell Development Regulation Of Actin Filament Depolymerization Sarcomere Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Cytoskeletal Protein Binding Striated Muscle Cell Development Phosphatidylinositol-4,5-bisphosphate Binding Regulation Of Transmembrane Transporter Activity Filopodium Regulation Of Potassium Ion Transport Actin Filament Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Protein Depolymerization Muscle Cell Development Negative Regulation Of Monoatomic Ion Transport Postsynaptic Density Membrane
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