GRM6

Description		glutamate metabotropic receptor 6
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Dendrite New Growing Cell Tip Cell Projection Synapse Cell Tip
	Molecular Function	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity G Protein-coupled Receptor Activity Protein Binding Glutamate Receptor Activity Protein Homodimerization Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Synapse Assembly Visual Perception Locomotory Behavior Detection Of Visible Light Gene Expression Detection Of Light Stimulus Involved In Visual Perception Sensory Perception Of Light Stimulus Regulation Of Synaptic Transmission, Glutamatergic Retina Development In Camera-type Eye Positive Regulation Of Calcium Ion Import Across Plasma Membrane
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs
Diseases		Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO)
GWAS		Dental caries (decayed and filled deciduous teeth) ( 31533690) Parent of origin effect on receptive language ability (paternal) ( 32635940) Pubertal anthropometrics ( 23449627) Refractive error ( 32231278)
Interacting Genes		2 interacting genes: CLK1 GNAO1
Entrez ID		2916
HPRD ID		04975
Ensembl ID		ENSG00000113262
Uniprot IDs		O15303
PDB IDs
Enriched GO Terms of Interacting Partners?		Mu-type Opioid Receptor Binding Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity G Protein-coupled Serotonin Receptor Binding Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Parallel Fiber To Purkinje Cell Synapse G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Protein Serine/threonine/tyrosine Kinase Activity Postsynaptic Modulation Of Chemical Synaptic Transmission Heterotrimeric G-protein Complex Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Insulin Secretion Vesicle Docking Involved In Exocytosis Negative Regulation Of Peptide Secretion Nucleotide Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Hormone Secretion Membrane Docking Cell Body Negative Regulation Of Protein Secretion Vesicle Docking Organelle Localization By Membrane Tethering G Protein Activity GABA-ergic Synapse
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