CCDC66

Description		coiled-coil domain containing 66
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Axoneme Cell Junction Midbody Centriolar Satellite Ciliary Transition Zone Ciliary Basal Body Cell Projection Flemming Body
	Molecular Function	Protein Binding Microtubule Binding Protein Homodimerization Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation Microtubule Bundle Formation Retina Homeostasis Microtubule Nucleation Mitotic Spindle Organization Mitotic Metaphase Chromosome Alignment Cell Projection Organization Regulation Of Cytokinesis Detection Of Light Stimulus Involved In Visual Perception Cell Division Cilium Assembly Mitotic Spindle Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Protein Localization To Cilium Ciliary Transition Zone Assembly
Pathways
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 25673412 34021172) Lymphocyte count ( 32888494) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Refractive error ( 32231278)
Interacting Genes		1 interacting genes: CFTR
Entrez ID		285331
HPRD ID		14569
Ensembl ID		ENSG00000180376
Uniprot IDs		A2RUB6
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Cellular Response To Forskolin Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Bicarbonate Transport Water Transport Multicellular Organismal-level Water Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Transepithelial Transport Vesicle Docking Involved In Exocytosis Positive Regulation Of Transporter Activity ABC-type Transporter Activity Sterol Biosynthetic Process Chloride Channel Complex Positive Regulation Of Biomineral Tissue Development Cellular Response To CAMP Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Vesicle Docking Cholesterol Transport Clathrin-coated Endocytic Vesicle Membrane Odontogenesis Of Dentin-containing Tooth Chloride Channel Activity Multicellular Organismal-level Chemical Homeostasis Regulation Of Cellular PH Regulation Of Transmembrane Transporter Activity Membrane Docking Positive Regulation Of Exocytosis
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