SLC9A9

Description		solute carrier family 9 member A9
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Early Endosome Plasma Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Early Phagosome Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Protein Binding Antiporter Activity Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity
	Biological Process	Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Regulation Of PH Sodium Ion Transmembrane Transport Defense Response To Bacterium Regulation Of Intracellular PH Transmembrane Transport Potassium Ion Transmembrane Transport Phagosome Maturation Sodium Ion Import Across Plasma Membrane Proton Transmembrane Transport
Pathways		Sodium/Proton exchangers Defective SLC9A9 causes autism 16 (AUTS16)
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 20732626) Gut microbiota (functional units) ( 27694959) Hip circumference adjusted for BMI ( 28552196) IgG N-glycosylation phenotypes (multivariate analysis) ( 33710309) Mean platelet volume ( 32888494) Metabolite levels ( 23823483) N-glycan levels ( 21908519) Night sleep phenotypes ( 27126917) Non-alcoholic fatty liver disease histology (other) ( 20708005) Opioid requirements during laparoscopic-assisted colectomy ( 29207912) Pre-treatment viral load in HIV-1 infection ( 31219150) Response to angiotensin II receptor blocker therapy ( 22566498) Response to carboplatin and paclitaxel in ovarian cancer (MTT IC50) ( 27047539) Response to cholinesterase inhibitors in Alzheimer's disease ( 23374588) Rheumatoid arthritis ( 23143596) Survival in sporadic amyotrophic lateral sclerosis ( 27244217) Systolic blood pressure x quantitative lifestyle risk score interaction (1df test) ( 32227373) Systolic blood pressure x quantitative lifestyle risk score interaction (2df test) ( 32227373) Tonometry ( 17903302) Ulna and radius bone mineral density ( 30172743) Working memory ( 31598132)
Interacting Genes		3 interacting genes: OPRM1 TP53 ZDHHC17
Entrez ID		285195
HPRD ID		12226
Ensembl ID		ENSG00000181804
Uniprot IDs		Q8IVB4
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Regulation Of NMDA Receptor Activity Cellular Response To Morphine Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Histone Deacetylase Regulator Activity Negative Regulation Of Pentose-phosphate Shunt Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Response To Actinomycin D T Cell Proliferation Involved In Immune Response Negative Regulation Of Helicase Activity Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of G1 To G0 Transition Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Glial Cell Apoptotic Process Cellular Response To UV-C Germ Cell Nucleus Cellular Response To Actinomycin D ATP-dependent DNA/DNA Annealing Activity Protein-cysteine S-myristoyltransferase Activity Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Positive Regulation Of Cell Communication G Protein-coupled Opioid Receptor Activity Positive Regulation Of Signaling B Cell Lineage Commitment Regulation Of Pentose-phosphate Shunt Mitochondrial DNA Repair Regulation Of Cellular Response To Growth Factor Stimulus Bone Marrow Development Stress-induced Premature Senescence Protein-cysteine S-stearoyltransferase Activity Regulation Of Neurogenesis Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of NADP Metabolic Process Negative Regulation Of MiRNA Processing Regulation Of Intracellular Signal Transduction G Protein-coupled Opioid Receptor Signaling Pathway Behavioral Response To Ethanol TFIID-class Transcription Factor Complex Binding
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