TTLL6

Description		tubulin tyrosine ligase like 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Ciliary Basal Body Cell Projection 9+0 Non-motile Cilium
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Tubulin Binding Ligase Activity Metal Ion Binding Protein-glutamic Acid Ligase Activity Tubulin-glutamic Acid Ligase Activity Protein-glutamic Acid Ligase Activity, Initiating Protein-glutamic Acid Ligase Activity, Elongating
	Biological Process	Microtubule Bundle Formation Positive Regulation Of Cilium Movement Protein Polyglutamylation Microtubule Severing Regulation Of Cilium Beat Frequency Involved In Ciliary Motility
Pathways		Carboxyterminal post-translational modifications of tubulin
Drugs
Diseases
GWAS		Pulse pressure ( 30578418) Resting-state electroencephalogram vigilance ( 29703947) Type 2 diabetes ( 30297969)
Interacting Genes		1 interacting genes: APP
Entrez ID		284076
HPRD ID		08763
Ensembl ID		ENSG00000170703
Uniprot IDs		A0AAA9X7X9 Q8N841
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Neuron Projection Maintenance RAGE Receptor Binding
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