TMPRSS12

Description		transmembrane serine protease 12
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Plasma Membrane Membrane Cytoplasmic Vesicle
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Acrosome Assembly Proteolysis Spermatogenesis Single Fertilization Binding Of Sperm To Zona Pellucida Protein Processing Cell Differentiation Positive Regulation Of Sperm Capacitation
Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301)
Interacting Genes		1 interacting genes: BRCA1
Entrez ID		283471
HPRD ID		07133
Ensembl ID		ENSG00000186452
Uniprot IDs		A0A140VJY1 Q86WS5
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Negative Regulation Of Centrosome Duplication Negative Regulation Of Centriole Replication BRCA1-A Complex XY Body BRCA1-B Complex Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Lateral Element Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol BRCA1-C Complex Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gamma-tubulin Ring Complex Ubiquitin-modified Histone Reader Activity Response To Indole-3-methanol DNA Strand Resection Involved In Replication Fork Processing DNA Repair Complex Random Inactivation Of X Chromosome RNA Polymerase Binding Negative Regulation Of Fatty Acid Biosynthetic Process Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Regulation Of DNA Damage Checkpoint Regulation Of Centriole Replication Protein K6-linked Ubiquitination Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Condensed Chromosome Mitotic G2 DNA Damage Checkpoint Signaling Postreplication Repair Negative Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Homologous Recombination Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Regulation Of Centrosome Duplication Regulation Of Vascular Endothelial Growth Factor Production Centrosome Cycle Condensed Nuclear Chromosome Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Male Germ Cell Nucleus Mitotic G2/M Transition Checkpoint Regulation Of Centrosome Cycle Tubulin Binding Negative Regulation Of Lipid Biosynthetic Process Mitotic DNA Integrity Checkpoint Signaling Damaged DNA Binding
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