NAAA

Description		N-acylethanolamine acid amidase
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GO Annotations	Cellular Component	Cytoplasm Lysosome Membrane Lysosomal Lumen Extracellular Exosome
	Molecular Function	Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds N-acylsphingosine Amidohydrolase Activity Fatty Acid Amide Hydrolase Activity N-(long-chain-acyl)ethanolamine Deacylase Activity DNA-binding Transcription Factor Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Sphingosine Metabolic Process Lipid Catabolic Process N-acylethanolamine Metabolic Process N-acylphosphatidylethanolamine Metabolic Process
Pathways		Neurotransmitter release cycle
Drugs		Cannabidiol Medical Cannabis Nabiximols
Diseases
GWAS		Blood protein levels ( 30072576) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Hippocampal volume ( 29274321) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		1 interacting genes: APP
Entrez ID		27163
HPRD ID		12122
Ensembl ID		ENSG00000138744
Uniprot IDs		Q02083
PDB IDs		6DXW 6DXX
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Neuron Projection Maintenance RAGE Receptor Binding
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