GGT5

Description		gamma-glutamyltransferase 5
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane
	Molecular Function	Peptidyltransferase Activity Leukotriene-C(4) Hydrolase Peptidase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Glutathione Hydrolase Activity Leukotriene C4 Gamma-glutamyl Transferase Activity
	Biological Process	Proteolysis Amino Acid Metabolic Process Fatty Acid Metabolic Process Glutathione Metabolic Process Glutathione Biosynthetic Process Glutathione Catabolic Process Inflammatory Response Leukotriene Biosynthetic Process Leukotriene D4 Biosynthetic Process
Pathways		Glutathione synthesis and recycling Synthesis of Leukotrienes (LT) and Eoxins (EX) Aflatoxin activation and detoxification LTC4-CYSLTR mediated IL4 production Paracetamol ADME
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Amyotrophic lateral sclerosis ( 23624525) Eosinophil count ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Sum eosinophil basophil counts ( 27863252) Waist-to-hip ratio adjusted for BMI ( 28552196) White blood cell count ( 32888494) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Novel Interacting Genes		1 novel interacting genes: ADORA2A
Interacting Genes
Entrez ID		2687
HPRD ID		00666
Ensembl ID		ENSG00000099998
Uniprot IDs		B4DEL3 P36269
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Neurotransmitter Secretion Regulation Of Norepinephrine Secretion Regulation Of Acetylcholine Secretion, Neurotransmission Positive Regulation Of Circadian Rhythm Purinergic Nucleotide Receptor Signaling Pathway Regulation Of Urine Volume Synaptic Transmission, Dopaminergic Prepulse Inhibition Inhibitory Postsynaptic Potential Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Urine Volume Synaptic Transmission, Cholinergic Positive Regulation Of Long-term Synaptic Potentiation Astrocyte Activation G Protein-coupled Adenosine Receptor Activity Asymmetric Synapse Regulation Of Glutamate Secretion Positive Regulation Of Glutamate Secretion Axolemma Alpha-actinin Binding Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Amino Acid Transport Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle Response To Caffeine G Protein-coupled Adenosine Receptor Signaling Pathway Negative Regulation Of Vascular Permeability Positive Regulation Of Acetylcholine Secretion, Neurotransmission Type 5 Metabotropic Glutamate Receptor Binding Positive Regulation Of Behavior Eating Behavior Response To Amphetamine Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Synaptic Transmission, GABAergic Presynaptic Active Zone Regulation Of Catecholamine Secretion Presynaptic Modulation Of Chemical Synaptic Transmission Blood Circulation Regulation Of Long-term Synaptic Potentiation Synaptic Transmission, Glutamatergic Response To Amine Regulation Of Vascular Permeability Negative Regulation Of Alpha-beta T Cell Activation Cellular Defense Response Membrane Depolarization Vasodilation Excitatory Postsynaptic Potential Regulation Of Mitochondrial Membrane Potential Regulation Of Synaptic Transmission, Glutamatergic
Tagcloud ?