FBXO8

Gene Name		F-box protein 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Trans-Golgi Network Cell Junction
	Molecular Function	ARF Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Vesicle-mediated Transport Actin Cytoskeleton Organization Regulation Of ARF Protein Signal Transduction Positive Regulation Of GTPase Activity
Pathways
Drugs
Diseases
GWAS		Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-protein Interactions		2 interactors: MYC SKP1
Entrez ID		26269
HPRD ID		07293
Ensembl ID		ENSG00000164117
Uniprot IDs		G5E9Z0 Q8IXA8 Q9NRD0
PDB IDs
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Fibroblast Apoptotic Process Positive Regulation Of Proteolysis Negative Regulation Of Monocyte Differentiation Positive Regulation Of Cell Proliferation Involved In Kidney Development Chromatin Modification Regulation Of Proteolysis Chromatin Organization Histone H2A Monoubiquitination Regulation Of Monocyte Differentiation Histone H2A Ubiquitination Regulation Of Telomere Maintenance Positive Regulation Of DNA Biosynthetic Process Histone Monoubiquitination Chromosome Organization Cell Cycle Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Oxygen Transport Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Histone Ubiquitination Negative Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Kidney Development Cell Cycle Protein Monoubiquitination Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of DNA Biosynthetic Process Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Catalytic Activity Negative Regulation Of Myeloid Leukocyte Differentiation Response To Gamma Radiation Cellular Response To Drug Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Cellular Response To UV Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Response To DNA Damage Stimulus Ureteric Bud Morphogenesis Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Ligase Activity Negative Regulation Of Cell Division Nephron Morphogenesis Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Renal Tubule Morphogenesis
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