ABCA12

Description		ATP binding cassette subfamily A member 12
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Transport Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Epidermal Lamellar Body Epidermal Lamellar Body Membrane
	Molecular Function	Nucleotide Binding Signaling Receptor Binding Lipid Transporter Activity Protein Binding ATP Binding ATP Hydrolysis Activity ATPase-coupled Lipid Transmembrane Transporter Activity Apolipoprotein A-I Receptor Binding ATPase-coupled Transmembrane Transporter Activity ATPase-coupled Intramembrane Lipid Transporter Activity ABC-type Transporter Activity
	Biological Process	Corneocyte Desquamation Ceramide Metabolic Process Lipid Transport Intracellular Protein Transport Positive Regulation Of Cholesterol Efflux Cellular Homeostasis Keratinocyte Differentiation Keratinization Positive Regulation Of Cholesterol Transport Positive Regulation Of Intracellular Lipid Transport Secretion By Cell Cholesterol Efflux Phospholipid Efflux Lipid Translocation Ceramide Transport Surfactant Homeostasis Skin Morphogenesis Regulated Exocytosis Regulation Of Keratinocyte Differentiation Lung Alveolus Development Establishment Of Localization In Cell Transmembrane Transport Lipid Homeostasis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Establishment Of Skin Barrier Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Surface
Pathways		ABC transporters in lipid homeostasis Defective ABCA12 causes ARCI4B
Drugs
Diseases		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE) Harlequin ichthyosis
GWAS
Interacting Genes		1 interacting genes: MTDH
Entrez ID		26154
HPRD ID		07416
Ensembl ID		ENSG00000144452
Uniprot IDs		B3KVV3 Q86UK0
PDB IDs
Enriched GO Terms of Interacting Partners?		Intercellular Canaliculus
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