ARHGEF26

Description		Rho guanine nucleotide exchange factor 26
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GO Annotations	Cellular Component	Ruffle Cytosol Cell Projection
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Endothelial Cell Morphogenesis Regulation Of Actin Cytoskeleton Organization Ruffle Assembly
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body size at age 10 ( 32376654) Coronary artery disease ( 28714974 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 30224653) Myocardial infarction ( 33532862) Systolic blood pressure ( 30578418)
Interacting Genes		3 interacting genes: CDC42 DLG1 RAC1
Entrez ID		26084
HPRD ID		11554
Ensembl ID		ENSG00000114790
Uniprot IDs		A0A140VJU4 B3KXG0 Q96DR7
PDB IDs		6MYE 7YKG
Enriched GO Terms of Interacting Partners?		Cell-cell Junction Organization Positive Regulation Of Supramolecular Fiber Organization Thioesterase Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Actin Filament Organization Actin Filament Organization GTP-dependent Protein Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Lamellipodium Organization Positive Regulation Of Lamellipodium Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Actin Cytoskeleton Organization Phagocytosis, Engulfment Regulation Of Supramolecular Fiber Organization Actin Filament Polymerization Actin Filament-based Process Regulation Of Lamellipodium Assembly Regulation Of Protein-containing Complex Assembly Protein Kinase Binding Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Cell Junction Organization Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Stress Fiber Assembly Regulation Of Lamellipodium Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Membrane Invagination Positive Regulation Of Organelle Organization Non-canonical Wnt Signaling Pathway Supramolecular Fiber Organization Cortical Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Regulation Of Cytoskeleton Organization Actin Polymerization Or Depolymerization Glutamatergic Synapse Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Actin Filament Bundle Assembly G Protein Activity Membrane Organization Regulation Of MAPK Cascade Protein Polymerization Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of Protein Polymerization Positive Regulation Of Protein Localization To Membrane Regulation Of Stress Fiber Assembly Regulation Of Cell Adhesion
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