AUTS2

Description		activator of transcription and developmental regulator AUTS2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Actin Cytoskeleton Growth Cone Cell Projection
	Molecular Function	Chromatin Binding Protein Binding
	Biological Process	Neuron Migration Positive Regulation Of Lamellipodium Assembly Actin Cytoskeleton Organization Positive Regulation Of Rac Protein Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Axon Extension Dendrite Extension
Pathways		RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Alcohol consumption ( 31358974 21471458) Alcohol consumption (drinks per week) ( 30679032) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Appendicular lean mass ( 33097823) Bipolar disorder ( 22925353) Body mass index ( 25673413 28892062) Cerebrospinal fluid p-tau levels in normal cognition ( 29274321) Childhood ear infection ( 27182965 28928442) Chronotype ( 30696823) Coffee consumption ( 31046077) Cognitive decline (age-related) ( 28078323) Declining hemoglobin trajectory in blood donors ( 33491795) Diastolic blood pressure ( 30224653) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Hearing loss in noise exposure ( 33242228) Immune reponse to smallpox (secreted IL-2) ( 22610502) Irritable mood ( 29500382) Lymphocyte count ( 32888494) Male-pattern baldness ( 29146897 22693459 27182965 28196072) Mean corpuscular hemoglobin ( 32888494) Monobrow ( 27182965) Mosquito bite size ( 28199695) Motion sickness ( 25628336) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) QT interval ( 29213071) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to serotonin reuptake inhibitors in non-psychotic unipolar depression ( 26348319) Sleep duration ( 30531941) Smoking initiation ( 33082346) Type 2 diabetes ( 32499647 31118516 30718926) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Walking pace ( 33128006)
Interacting Genes		2 interacting genes: CSNK2A1 KRTAP6-3
Entrez ID		26053
HPRD ID		06276
Ensembl ID		ENSG00000158321
Uniprot IDs		A0A024RDL5 A0A2R8Y8C6 Q8WXX7
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Aggrephagy Aggrephagy Double-strand Break Repair Via Classical Nonhomologous End Joining Protein Targeting To Vacuole Involved In Autophagy Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Methylguanosine-cap Decapping Sin3-type Complex PcG Protein Complex Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Execution Phase Of Apoptosis RNA Decapping Protein Localization To Site Of Double-strand Break
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