PLEKHG3

Description		pleckstrin homology and RhoGEF domain containing G3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton
	Molecular Function	Actin Binding Guanyl-nucleotide Exchange Factor Activity Small GTPase Binding
	Biological Process	Regulation Of Cell Migration Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Establishment Of Cell Polarity
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Mean spheric corpuscular volume ( 32888494) Optic disc size ( 31809533) Platelet distribution width ( 32888494) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		1 interacting genes: CDC42
Entrez ID		26030
HPRD ID		17861
Ensembl ID		ENSG00000126822
Uniprot IDs		A0A2X0SFH4 A1L390
PDB IDs
Enriched GO Terms of Interacting Partners?		Leading Edge Membrane Thioesterase Binding Positive Regulation Of Pinocytosis Apolipoprotein A-I Receptor Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Endothelin Receptor Signaling Pathway Involved In Heart Process Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Neuropilin Signaling Pathway GBD Domain Binding Golgi Transport Complex Storage Vacuole Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Golgi Localization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Dendritic Cell Migration Establishment Of Monopolar Cell Polarity GTP-dependent Protein Binding Heart Contraction Cardiac Conduction System Development Embryonic Heart Tube Development Dendritic Spine Morphogenesis Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Establishment Or Maintenance Of Monopolar Cell Polarity Cell Migration Involved In Heart Development Polarized Epithelial Cell Differentiation Positive Regulation Of Lamellipodium Assembly Spindle Midzone Nuclear Migration Establishment Of Epithelial Cell Polarity Positive Regulation Of Filopodium Assembly Nucleus Localization Heart Process Dendritic Spine Organization Phagocytosis, Engulfment Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lamellipodium Organization Macrophage Differentiation Neuron Projection Organization Substantia Nigra Development Regulation Of Filopodium Assembly Regulation Of Lamellipodium Assembly Cell Fate Determination Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
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