ULK3

Description		unc-51 like kinase 3
Image
GO Annotations	Cellular Component	Phagophore Assembly Site Cytoplasm Autophagosome Cytosol Phagophore Assembly Site Membrane Ciliary Tip
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Autophagosome Assembly Mitophagy Autophagy Smoothened Signaling Pathway Regulation Of Autophagy Piecemeal Microautophagy Of The Nucleus Response To Starvation Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Smoothened Signaling Pathway Protein Autophosphorylation Reticulophagy Fibroblast Activation Cellular Senescence
Pathways		Hedgehog 'on' state
Drugs		Fostamatinib
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Caffeine consumption ( 21490707) Celiac disease ( 25920553) Coffee consumption ( 21876539) Diastolic blood pressure ( 21909115 19430479 26390057 27618452 27841878 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hemoglobin levels ( 32327693) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 27618448) Neutrophil percentage of white cells ( 27863252) Systolic blood pressure ( 28739976 27841878 27618452 21909115) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		2 interacting genes: CFTR UBC
Entrez ID		25989
HPRD ID		15609
Ensembl ID		ENSG00000140474
Uniprot IDs		B4DDG2 Q6PHR2
PDB IDs		4WZX 6FDY 6FDZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Endosome Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Cellular Response To Forskolin Golgi-associated Vesicle Membrane Protein Tag Activity Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Bicarbonate Transport Water Transport Multicellular Organismal-level Water Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding Endoplasmic Reticulum Membrane Fluid Transport Transepithelial Transport Vesicle Docking Involved In Exocytosis Positive Regulation Of Transporter Activity ABC-type Transporter Activity Sterol Biosynthetic Process Chloride Channel Complex Positive Regulation Of Biomineral Tissue Development Cellular Response To CAMP Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Vesicle Docking Cholesterol Transport Clathrin-coated Endocytic Vesicle Membrane Odontogenesis Of Dentin-containing Tooth Chloride Channel Activity Multicellular Organismal-level Chemical Homeostasis Regulation Of Cellular PH
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