KBTBD2

Description		kelch repeat and BTB domain containing 2
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GO Annotations	Cellular Component	Cytoplasm Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Glucose Metabolic Process Lipid Metabolic Process Gene Expression Protein Ubiquitination Response To Insulin Cellular Response To Insulin Stimulus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein K48-linked Ubiquitination Regulation Of Cellular Response To Insulin Stimulus
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Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Chronotype ( 30696823) Estimated glomerular filtration rate ( 31152163) Glomerular filtration rate (creatinine) ( 26831199) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Mean corpuscular hemoglobin ( 32888494) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		1 interacting genes: PIK3R1
Entrez ID		25948
HPRD ID		13756
Ensembl ID		ENSG00000170852
Uniprot IDs		A0A024RA38 Q8IY47
PDB IDs		8GQ6 8H33 8H34 8H35 8H36 8H37 8H38 8H3A 8H3F 8H3R
Enriched GO Terms of Interacting Partners?		Kinase Regulator Activity Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Activator Activity Phosphatidylinositol 3-kinase Complex, Class IA Insulin Binding Perinuclear Endoplasmic Reticulum Membrane 1-phosphatidylinositol-3-kinase Regulator Activity Phosphatidylinositol Kinase Activity Positive Regulation Of Focal Adhesion Disassembly Neurotrophin TRKA Receptor Binding Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Phosphatidylinositol 3-kinase Regulator Activity T Follicular Helper Cell Differentiation ErbB-3 Class Receptor Binding Kinase Activator Activity Insulin Receptor Substrate Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Interleukin-18-mediated Signaling Pathway Enzyme-substrate Adaptor Activity Insulin-like Growth Factor Receptor Binding Phosphatidylinositol 3-kinase Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors T-helper Cell Differentiation Regulation Of Toll-like Receptor 4 Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Stress Fiber Assembly Insulin Receptor Binding Growth Hormone Receptor Signaling Pathway Negative Regulation Of Osteoclast Differentiation Phosphotyrosine Residue Binding Positive Regulation Of Lamellipodium Assembly Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Cell-matrix Adhesion Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of D-glucose Import Regulation Of Lamellipodium Assembly Positive Regulation Of D-glucose Transmembrane Transport Osteoclast Differentiation Substrate Adhesion-dependent Cell Spreading T Cell Differentiation Involved In Immune Response Positive Regulation Of RNA Splicing Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Filopodium Assembly Positive Regulation Of Lamellipodium Organization Natural Killer Cell Mediated Immunity Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Protein Import Into Nucleus Regulation Of Filopodium Assembly Cis-Golgi Network
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