ASPM

Description		assembly factor for spindle microtubules
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Spindle Cytoskeleton Microtubule Apical Plasma Membrane Midbody Microtubule Minus-end Meiotic Spindle Mitotic Spindle Pole
	Molecular Function	Calmodulin Binding
	Biological Process	Neuron Migration Positive Regulation Of Neuroblast Proliferation Spindle Organization Spermatogenesis Neuroblast Proliferation Brain Development Asymmetric Cell Division Male Gonad Development Forebrain Neuroblast Division Cerebral Cortex Development Negative Regulation Of Neuron Differentiation Negative Regulation Of Asymmetric Cell Division Oogenesis Developmental Growth Cell Division Regulation Of Meiotic Cell Cycle Spindle Localization Maintenance Of Centrosome Location Positive Regulation Of Canonical Wnt Signaling Pathway Meiotic Spindle Assembly Neuronal Stem Cell Population Maintenance
Pathways
Drugs
Diseases		Primary microcephaly (MCPH)
GWAS		Age-related macular degeneration ( 23536807) Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Lupus nephritis in systemic lupus erythematosus ( 24925725) Matrix metalloproteinase-8 levels ( 29212897)
Interacting Genes		4 interacting genes: LIG4 PLK1 PPP1CA USP7
Entrez ID		259266
HPRD ID		08384
Ensembl ID		ENSG00000066279
Uniprot IDs		B3KWI2 Q8IZT6
PDB IDs
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair Via Nonhomologous End Joining DNA Repair Double-strand Break Repair Via Alternative Nonhomologous End Joining DNA Metabolic Process DNA Damage Response Double-strand Break Repair Regulation Of Chromosome Organization Chromosome Organization Regulation Of Protein Stability Cellular Response To Stress Cell Division Nucleic Acid Metabolic Process Regulation Of Glucose Metabolic Process Establishment Of Integrated Proviral Latency Regulation Of Circadian Rhythm Organelle Organization Regulation Of Cellular Component Organization Nucleobase-containing Compound Metabolic Process Establishment Of Viral Latency Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Synaptonemal Complex Disassembly Golgi Inheritance RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Magnesium Ion Binding DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Chromosome, Telomeric Region DNA Ligase Activity DN2 Thymocyte Differentiation Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Symbiont-mediated Disruption Of Host Cell PML Body Response To Stress DNA Recombination Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Protein Stabilization Regulation Of Organelle Organization Nucleotide-excision Repair, DNA Gap Filling Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Rhythmic Process Glycogen Granule Regulation Of Establishment Of Protein Localization To Telomere DNA-dependent Protein Kinase-DNA Ligase 4 Complex
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