NALCN

Description		sodium leak channel, non-selective
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GO Annotations	Cellular Component	Plasma Membrane Membrane Monoatomic Ion Channel Complex
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding Leak Channel Activity
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Synaptic Transmission, GABAergic Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Transmembrane Transport Regulation Of Resting Membrane Potential Calcium Ion Transmembrane Transport Potassium Ion Transmembrane Transport
Pathways		Stimuli-sensing channels
Drugs
Diseases
GWAS		Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Bipolar disorder and eating disorder ( 26433762) Bipolar disorder and schizophrenia ( 20889312) Fasting insulin ( 34074324) HIV-associated dementia ( 22628157) Night sleep phenotypes ( 27126917) Non-small cell lung cancer ( 23144319) Prudent dietary pattern ( 28644415) Psychosis (atypical) ( 24132900) Recurrent major depressive disorder ( 29317602) Refractive error ( 32231278) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		2 interacting genes: LMNA MEOX2
Entrez ID		259232
HPRD ID		15647
Ensembl ID		ENSG00000102452
Uniprot IDs		A0A6Q8PF19 A0A6Q8PFS9 Q8IZF0
PDB IDs		6XIW 7CM3 7SX3 7SX4 7WJI
Enriched GO Terms of Interacting Partners?		Nuclear Speck Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Lamin Filament DNA Double-strand Break Attachment To Nuclear Envelope Nuclear Pore Localization Structural Constituent Of Nuclear Lamina Somite Specification Negative Regulation Of Mesenchymal Cell Proliferation Ventricular Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Nuclear Lamina Protein Localization To Nuclear Envelope Segment Specification Somite Development Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Nuclear Envelope Organization Regulation Of Cell Migration Nuclear Migration Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Cell Motility Nucleus Localization Regulation Of Locomotion Regulation Of Mesenchymal Cell Proliferation Nuclear Lumen Negative Regulation Of Muscle Hypertrophy Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Release Of Cytochrome C From Mitochondria Cardiac Cell Development Regulation Of Cell Migration Involved In Sprouting Angiogenesis Limb Development Negative Regulation Of Blood Vessel Endothelial Cell Migration Embryonic Pattern Specification Cellular Senescence Striated Muscle Cell Development Protein-containing Complex Localization Regulation Of Cardiac Muscle Hypertrophy Skeletal Muscle Tissue Development Negative Regulation Of Endothelial Cell Migration Roof Of Mouth Development Chromosome Localization Nucleus Organization Muscle Cell Development Structural Constituent Of Cytoskeleton Site Of Double-strand Break Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Telomere Maintenance
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