GALNT3

Description		polypeptide N-acetylgalactosaminyltransferase 3
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane Golgi Cisterna Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Polypeptide N-acetylgalactosaminyltransferase Activity Calcium Ion Binding Protein Binding Transferase Activity Glycosyltransferase Activity Manganese Ion Binding Carbohydrate Binding Metal Ion Binding
	Biological Process	Endochondral Ossification Chondrocyte Development Carbohydrate Metabolic Process Polysaccharide Metabolic Process Protein Glycosylation Protein O-linked Glycosylation Apoptotic Process Spermatogenesis Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression Protein O-linked Glycosylation Via N-acetyl-galactosamine Multicellular Organism Growth Cell Maturation Chondroitin Sulfate Proteoglycan Biosynthetic Process Limb Development
Pathways		FGFR3c ligand binding and activation Defective GALNT3 causes HFTC O-linked glycosylation of mucins
Drugs
Diseases
GWAS		Bone mineral density ( 21533022) Bone mineral density (paediatric, lower limb) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) Lumbar spine bone mineral density ( 22504420) Serum alkaline phosphatase levels ( 33547301) Spontaneous preterm birth with premature rupture of membranes ( 31194736)
Novel Interacting Genes		1 novel interacting genes: LRP2
Interacting Genes		2 interacting genes: APPBP2 MAPK8IP2
Entrez ID		2591
HPRD ID		03453
Ensembl ID		ENSG00000115339
Uniprot IDs		Q14435
PDB IDs
Enriched GO Terms of Interacting Partners?		Specification Of Animal Organ Identity Transcytosis Pulmonary Artery Morphogenesis Folic Acid Transport Cranial Skeletal System Development Cell Projection Morphogenesis Folate Import Across Plasma Membrane Hormone Binding Regulation Of Oligodendrocyte Progenitor Proliferation Ventricular Compact Myocardium Morphogenesis Positive Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Oligodendrocyte Progenitor Proliferation Vitamin D Metabolic Process Coronary Vasculature Morphogenesis Regulation Of Lysosomal Protein Catabolic Process Folate Transmembrane Transport Response To Leptin Cobalamin Transport Insulin-like Growth Factor I Binding Low-density Lipoprotein Particle Receptor Activity Positive Regulation Of Protein Catabolic Process In The Vacuole Neuron Projection Morphogenesis Female Genitalia Development Heart Field Specification Coronary Artery Morphogenesis Vitamin Transmembrane Transport Vagina Development Secondary Heart Field Specification Protein Transporter Activity Cul2-RING Ubiquitin Ligase Complex MAP-kinase Scaffold Activity Signal Complex Assembly Positive Regulation Of Stress-activated MAPK Cascade JUN Kinase Binding Nonassociative Learning Neuron Projection Arborization Mating Behavior Endosome Lumen Cargo Receptor Activity Amyloid-beta Clearance Coronary Vasculature Development Outflow Tract Septum Morphogenesis Diol Metabolic Process Aorta Development Ventricular Septum Development Reproductive Behavior Genitalia Development Microtubule Associated Complex Behavioral Fear Response Behavioral Defense Response
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