SERINC5

Description		serine incorporator 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Centrosome Cytosol Plasma Membrane Membrane Myelin Sheath Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	L-serine Transmembrane Transporter Activity Phospholipid Scramblase Activity
	Biological Process	Immune System Process L-serine Biosynthetic Process Lipid Metabolic Process Phosphatidylserine Metabolic Process Phospholipid Biosynthetic Process L-serine Transport Plasma Membrane Phospholipid Scrambling Myelination Innate Immune Response Defense Response To Virus Antiviral Innate Immune Response
Pathways		Serine metabolism
Drugs
Diseases
GWAS		Alzheimer's disease in APOE e4- carriers ( 25778476) Borderline personality disorder features ( 23979607) Fasting blood glucose ( 28371326) Sulfasalazine-induced agranulocytosis ( 28762467)
Novel Interacting Genes		1 novel interacting genes: FXR1
Interacting Genes		1 interacting genes: PTAFR
Entrez ID		256987
HPRD ID		12828
Ensembl ID		ENSG00000164300
Uniprot IDs		Q86VE9
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activating Factor Receptor Activity G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Inositol Trisphosphate Biosynthetic Process G Protein-coupled Purinergic Nucleotide Receptor Activity Inositol Trisphosphate Metabolic Process Lipopolysaccharide Immune Receptor Activity RNA Strand Annealing Activity Nuclear Pore Localization Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Intracellular Membraneless Organelle Inositol Phosphate Biosynthetic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing Nuclear Pore Complex Assembly Costamere Ribonucleoprotein Granule Nuclear Pore Organization Translation Regulator Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Pore Complex Assembly Skeletal Muscle Organ Development Inositol Phosphate Metabolic Process Purinergic Nucleotide Receptor Signaling Pathway MRNA 3'-UTR AU-rich Region Binding Dentate Gyrus Development Regulation Of Circadian Sleep/wake Cycle Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Rho Protein Signal Transduction Cytoplasmic Translational Initiation Lipopolysaccharide Binding Lipopolysaccharide-mediated Signaling Pathway Ribonucleoprotein Complex Binding Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Long-term Synaptic Potentiation Molecular Condensate Scaffold Activity Regulation Of Neuronal Synaptic Plasticity Tertiary Granule Membrane Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Protein-containing Complex Localization Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of MRNA Catabolic Process Regulation Of Behavior Translational Initiation Cytoplasmic Ribonucleoprotein Granule Regulation Of Rho Protein Signal Transduction
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